Correlation between functional capacity and oxidative stress and inflammation in hemodialysis patients

Patients with chronic kidney disease (CKD) may present impaired functional capacity due to peripheral muscle involvement. Oxidative stress and inflammation are probably involved in this pathophysiology. This study aimed to evaluate the association between functional capacity and biomarkers of oxidat...

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Published in:Journal of bodywork and movement therapies 2021-07, Vol.27, p.339-343
Main Authors: Silva, Ítalo Caldas, Marizeiro, Débora Fortes, De Francesco Daher, Elizabeth, Veras de Sandes-Freitas, Tainá, Meneses, Gdayllon Cavalcante, Bezerra, Gabriela Freire, Libório, Alexandre Braga, Costa Martins, Alice Maria, Campos, Nataly Gurgel
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Language:English
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6-Min walk test
Biomarkers
Chronic kidney disease
Renal dialysis
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container_title Journal of bodywork and movement therapies
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creator Silva, Ítalo Caldas
Marizeiro, Débora Fortes
De Francesco Daher, Elizabeth
Veras de Sandes-Freitas, Tainá
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Bezerra, Gabriela Freire
Libório, Alexandre Braga
Costa Martins, Alice Maria
Campos, Nataly Gurgel
description Patients with chronic kidney disease (CKD) may present impaired functional capacity due to peripheral muscle involvement. Oxidative stress and inflammation are probably involved in this pathophysiology. This study aimed to evaluate the association between functional capacity and biomarkers of oxidative stress as well as biomarkers of inflammation in patients under chronic hemodialysis therapy. Cross-sectional study including 41 patients from a single hemodialysis center. Functional capacity was assessed through the 6-min walk test (6MWT). The assessed blood biomarkers were: malondialdehyde (MDA) (oxidative stress, TBARS method) and angiopoietin-2 (Ang-2) (inflammation, ELISA). The influence of gender on impairment of functional capacity was further explored. There was an inversely proportional correlation between the 6MWD and MDA (r = -,322 and p = 0.040) and Ang-2 (r = -, 376 and p = 0.016) values. 6MWD was 370.9 ± 101.2 m and 391.4 ± 108.2 m in women and men, respectively (p 
doi_str_mv 10.1016/j.jbmt.2021.01.002
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subjects 6-Min walk test
Biomarkers
Chronic kidney disease
Renal dialysis
title Correlation between functional capacity and oxidative stress and inflammation in hemodialysis patients
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