Evaluation of children and adolescent with cystic fibrosis by pancreatic elastography

• Published in: Pediatrics international 2022-01, Vol.64 (1), p.e14951-n/a
• Main Authors: Yılmaz, Kamil, Hattapoğlu, Salih, Şen, Velat, Karabel, Müsemma, Kan, Ahmet, Yılmaz, Engin Deniz, Selimoglu Sen, Hadice, Yılmaz, Sureyya
• Format: Article
• Language: English
• Subjects: Adolescent; Child; Chronic Disease; Cystic fibrosis; Cystic Fibrosis - diagnostic imaging; Cystic fibrosis transmembrane conductance regulator; Elasticity Imaging Techniques - methods; Exocrine Pancreatic Insufficiency - diagnosis; Exocrine Pancreatic Insufficiency - etiology; Female; Hereditary diseases; Humans; Male; Pancreas; Pancreas - diagnostic imaging; Patients; Pediatrics; Point mutation; point shear wave elastography; Statistical analysis
• ISSN: 1328-8067; 1442-200X
• DOI: 10.1111/ped.14951

Background Cystic fibrosis (CF) is an autosomal recessively inherited disease. Clinical findings vary by age of the patient, the organ systems involved, and the severity of the CFTR gene mutation. Pancreatic and liver involvement is prominent and exocrine pancreatic insufficiency is observed in the majority of patients. Point shear wave elastography (pSWE) is a non‐invasive method that can quantitatively determine tissue elasticity and stiffness. In this study, the morphological evaluation of the pancreas was performed using the pSWE technique in pediatric patients diagnosed with CF. The effectiveness of this method for the early detection of pancreatic insufficiency was investigated. Methods Fifty‐five patients with CF (24 girls, 31 boys) and 60 healthy children (29 girls, 31 boys) without any chronic diseases and who were suitable for the pSWE examination were included in the study. Results The mean value of pSWE was 1.12 ± 0.16 in the healthy group and 0.97 ± 0.16 in the patients with cystic fibrosis. There was a statistically significant difference between the two groups (P