Association between serum folate levels and blood concentrations of cadmium and lead in US adults

• Published in: Environmental science and pollution research international 2022, Vol.29 (3), p.3565-3574
• Main Authors: Wu, Zuxiang, Hu, Huan, Wang, Chenxi, Wu, Ji, Xiong, Yurong, Fu, Yang, Cheng, Xiaoshu, Su, Hai, Li, Ping
• Format: Article
• Language: English
• Subjects: Adults; animals; Aquatic Pollution; Atmospheric Protection/Air Quality Control/Air Pollution; Blood; Blood levels; blood serum; Cadmium; Detoxification; Earth and Environmental Science; Ecotoxicology; Environment; Environmental Chemistry; Environmental Health; Environmental science; Epidermal growth factor receptors; Female; females; Folic Acid; Glomerular filtration rate; Heavy metals; Humans; In vivo methods and tests; Lead; Lead poisoning; Male; males; Metals, Heavy; National Health and Nutrition Examination Survey; Nutrition; Nutrition Surveys; regression analysis; Research Article; Vitamin B; Waste Water Technology; Water Management; Water Pollution Control
• ISSN: 0944-1344; 1614-7499
• DOI: 10.1007/s11356-021-15767-5

Background Folate may be involved in the detoxification of heavy metals. This has been demonstrated in animal studies, in in vivo and in vitro studies, and clinical evaluations. However, knowledge regarding the associations between serum folate and blood concentrations of cadmium and lead is limited. Objective We aimed to investigate the relationship between serum folate levels and blood concentrations of cadmium and lead in US adults. Methods Data on 15,501 adults were obtained from the 1999–2006 National Health and Nutrition Examination Survey (NHANES) and used for the analysis. Information on serum folate concentrations and blood levels of lead and cadmium was derived from laboratory measurements in the NHANES. Multivariable linear regression was used to examine the relationship between serum folate levels and blood concentrations of cadmium and lead in US adults, controlling for confounders. Results The serum folate concentration was negatively correlated with blood levels of cadmium and lead ( P -trends 60 mL/min/1.73 m 2 ), the association between serum folate concentrations and blood levels of cadmium and lead was found to be more stable in adults with eGFR > 60 mL/min/1.73 m 2 , both in males and females. Significance These findings warrant future studies to explore the mechanisms responsible for the beneficial role of folate in regulating cadmium and lead concentrations in the blood.