Serum LAPTM4B-35 protein as a novel diagnostic marker for hepatocellular carcinoma

LAPTM4B-35 protein is one of the isoforms that are encoded by a cancer driver gene, . This gene was primarily found and identified in our lab of Peking University School of Basic Medical Sciences. The LAPTM4B-35 protein and its encoded mRNA are significantly over-expressed in a variety of cancers, s...

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Bibliographic Details
Published in:Beijing da xue xue bao. Journal of Peking University. Yi xue ban 2021-08, Vol.53 (4), p.710
Main Authors: Pang, Y, Zhang, S, Yang, H, Zhou, R L
Format: Article
Language:Chinese
Subjects:
Biomarkers, Tumor
Carcinoma, Hepatocellular - diagnosis
Humans
Liver Neoplasms - diagnosis
Male
Membrane Proteins - genetics
Oncogene Proteins
Prognosis
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Summary:LAPTM4B-35 protein is one of the isoforms that are encoded by a cancer driver gene, . This gene was primarily found and identified in our lab of Peking University School of Basic Medical Sciences. The LAPTM4B-35 protein and its encoded mRNA are significantly over-expressed in a variety of cancers, such as hepatocellular carcinoma (HCC), lung cancers (including non small-cell lung cancer and small-cell lung cancer), stomach cancer, colorectal carcinoma, pancreatic cancer, gallbladder cancer, cholangiocarcinoma, breast cancer, prostate cancer, ovarian cancer, cervical cancer, endometrial cancer, and so on. It has firmly demonstrated through lab experiments either or , as well as clinical studies that the over-expression of LAPTM4B-35 can promote cancer growth, metastasis, and multidrug resistance. Specially, the expressive level of LAPTM4B-35 is associa-ted with recurrence of HCC. The aim of this study is to identify the release of LAPTM4B-35 protein from hepatocellular carcinoma into blood of HCC patients and
ISSN:1671-167X