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In vitro evaluation of antimicrobial resistance selection in Neisseria gonorrhoeae

Highlights•We assessed the risk of mutant selection in Neisseria gonorrhoeae by antimicrobials. •Ertapenem may prevent mutant selection in N. gonorrhoeae. •Fluoroquinolones may restrict further resistance in a gyrA mutant of N. gonorrhoeae. •Ceftriaxone, azithromycin and doxycycline resistance in N....

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Published in:	International journal of antimicrobial agents 2021-10, Vol.58 (4), p.106417-106417, Article 106417
Main Authors:	Allen, George P, Deao, Kristina M, Hill, Stephanie A, Schipelliti, Sandra M, Tran, Thomas
Format:	Article
Language:	English
Subjects:	Anti-Bacterial Agents - pharmacology Azithromycin - pharmacology Ceftriaxone - pharmacology Ciprofloxacin - pharmacology Doxycycline - pharmacology Drug Resistance, Multiple, Bacterial - genetics Ertapenem - pharmacology Gentamicins - pharmacology Gonorrhea - drug therapy Humans Infectious Disease Levofloxacin - pharmacology Microbial Sensitivity Tests Moxifloxacin - pharmacology Mutant prevention concentration Mutant selection window Neisseria gonorrhoeae Neisseria gonorrhoeae - drug effects Neisseria gonorrhoeae - genetics
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description	Highlights•We assessed the risk of mutant selection in Neisseria gonorrhoeae by antimicrobials. •Ertapenem may prevent mutant selection in N. gonorrhoeae. •Fluoroquinolones may restrict further resistance in a gyrA mutant of N. gonorrhoeae. •Ceftriaxone, azithromycin and doxycycline resistance in N. gonorrhoeae will persist. •Use of gentamicin for gonorrhoea will likely lead to selection of resistant mutants.
doi_str_mv	10.1016/j.ijantimicag.2021.106417
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subjects	Anti-Bacterial Agents - pharmacology Azithromycin - pharmacology Ceftriaxone - pharmacology Ciprofloxacin - pharmacology Doxycycline - pharmacology Drug Resistance, Multiple, Bacterial - genetics Ertapenem - pharmacology Gentamicins - pharmacology Gonorrhea - drug therapy Humans Infectious Disease Levofloxacin - pharmacology Microbial Sensitivity Tests Moxifloxacin - pharmacology Mutant prevention concentration Mutant selection window Neisseria gonorrhoeae Neisseria gonorrhoeae - drug effects Neisseria gonorrhoeae - genetics
title	In vitro evaluation of antimicrobial resistance selection in Neisseria gonorrhoeae
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