L-valine production in Corynebacterium glutamicum based on systematic metabolic engineering: progress and prospects

L-valine is an essential branched-chain amino acid that cannot be synthesized by the human body and has a wide range of applications in food, medicine and feed. Market demand has stimulated people’s interest in the industrial production of L-valine. At present, the mutagenized or engineered Coryneba...

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Bibliographic Details
Published in:Amino acids 2021-09, Vol.53 (9), p.1301-1312
Main Authors: Liu, Jie, Xu, Jian-Zhong, Wang, Bingbing, Rao, Zhi-Ming, Zhang, Wei-Guo
Format: Article
Language:English
Subjects:
Amino acids
Analytical Chemistry
Biochemical Engineering
Biochemistry
Biomedical and Life Sciences
Biosynthesis
Biosynthetic Pathways
Chain branching
Corynebacterium glutamicum
Corynebacterium glutamicum - growth & development
Corynebacterium glutamicum - metabolism
Engineering
Fermentation
Humans
Life Sciences
Metabolic engineering
Metabolic Engineering - methods
Metabolic networks
Metabolic Networks and Pathways
Metabolism
Microorganisms
Neurobiology
Proteomics
Review Article
Upgrading
Valine
Valine - metabolism
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Summary:L-valine is an essential branched-chain amino acid that cannot be synthesized by the human body and has a wide range of applications in food, medicine and feed. Market demand has stimulated people’s interest in the industrial production of L-valine. At present, the mutagenized or engineered Corynebacterium glutamicum is an effective microbial cell factory for producing L-valine. Because the biosynthetic pathway and metabolic network of L-valine are intricate and strictly regulated by a variety of key enzymes and genes, highly targeted metabolic engineering can no longer meet the demand for efficient biosynthesis of L-valine. In recent years, the development of omics technology has promoted the upgrading of traditional metabolic engineering to systematic metabolic engineering. This whole-cell-scale transformation strategy has become a productive method for developing L-valine producing strains. This review provides an overview of the biosynthesis and regulation mechanism of L-valine, and summarizes the current metabolic engineering techniques and strategies for constructing L-valine high-producing strains. Finally, the opinion of constructing a cell factory for efficiently biosynthesizing L-valine was proposed.
ISSN:0939-4451
1438-2199
DOI:10.1007/s00726-021-03066-9