A multi-omics roadmap of β-cell failure in type 2 diabetes mellitus

Pancreatic β-cell dysfunction contributes to type 2 diabetes mellitus (T2DM) pathogenesis. However, human islet studies have revealed few consistent molecular changes in T2DM, owing partly to technical and biological confounding factors. A new multi-omics study of islets from well-phenotyped living...

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Bibliographic Details
Published in:Nature reviews. Endocrinology 2021-11, Vol.17 (11), p.641-642
Main Authors: Wang, Gaowei, Sander, Maike
Format: Article
Language:English
Subjects:
631/1647/2017
692/163/2743/137/773
Beta cells
Diabetes
Diabetes mellitus (non-insulin dependent)
Diabetes Mellitus, Type 1
Diabetes Mellitus, Type 2 - genetics
Endocrinology
Humans
Insulin-Secreting Cells
Medicine
Medicine & Public Health
News & Views
news-and-views
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Summary:Pancreatic β-cell dysfunction contributes to type 2 diabetes mellitus (T2DM) pathogenesis. However, human islet studies have revealed few consistent molecular changes in T2DM, owing partly to technical and biological confounding factors. A new multi-omics study of islets from well-phenotyped living donors attempts to overcome these limitations to catalogue T2DM-associated molecular changes.
ISSN:1759-5029
1759-5037
DOI:10.1038/s41574-021-00556-4