Association between global DNA methylation (LINE-1) and occupational particulate matter exposure among informal electronic-waste recyclers in Ghana

This study examined the associations between PM (2.5 and 10) and global DNA methylation among 100 e-waste workers and 51 non-e-waste workers serving as controls. Long interspersed nucleotide repetitive elements-1 (LINE-1) was measured by pyrosequencing. Personal PM 2.5 and PM 10 were measured over a...

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Bibliographic Details
Published in:International journal of environmental health research 2022-11, Vol.32 (11), p.2406-2424
Main Authors: Issah, Ibrahim, Arko-Mensah, John, Rozek, Laura S., Rentschler, Katie, Agyekum, Thomas P., Dwumoh, Duah, Batterman, Stuart, Robins, Thomas G., Fobil, Julius N.
Format: Article
Language:English
Subjects:
2.5
CpG islands
Deoxyribonucleic acid
DNA
DNA methylation
e-waste
e-waste workers
Electronic waste
Exposure
LINE-1
Nucleotides
Occupational exposure
Particulate emissions
Particulate matter
Regression analysis
Regression models
Waste recycling
Workers
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Summary:This study examined the associations between PM (2.5 and 10) and global DNA methylation among 100 e-waste workers and 51 non-e-waste workers serving as controls. Long interspersed nucleotide repetitive elements-1 (LINE-1) was measured by pyrosequencing. Personal PM 2.5 and PM 10 were measured over a 4-hour work-shift using real-time particulate monitors incorporated into a backpack . Linear regression models were used to assess the association between PM and LINE-1 DNA methylation. The concentrations of PM 2.5 and PM 10 were significantly higher among the e-waste workers than the controls (77.32 vs 34.88, p
ISSN:0960-3123
1369-1619
DOI:10.1080/09603123.2021.1969007