Hippocampal atrophy and quantitative EEG markers in mild cognitive impairment in temporal lobe epilepsy versus extra-temporal lobe epilepsy

Objective Cognitive impairment in temporal lobe epilepsy is widely acknowledged as one of the most well-known comorbidities. This study aimed to explore cognitive impairment and to determine the potential clinical, radiological, and quantitative electroencephalography markers for cognitive impairmen...

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Bibliographic Details
Published in:Neurological sciences 2022-03, Vol.43 (3), p.1975-1986
Main Authors: Elsherif, Mohammed, Esmael, Ahmed
Format: Article
Language:English
Subjects:
Atrophy
Atrophy - pathology
Cognitive ability
Cognitive Dysfunction - diagnostic imaging
Cognitive Dysfunction - pathology
Convulsions
EEG
Electroencephalography
Epilepsy
Epilepsy, Temporal Lobe - complications
Epilepsy, Temporal Lobe - diagnostic imaging
Epilepsy, Temporal Lobe - pathology
Fever
Hippocampus
Hippocampus - diagnostic imaging
Hippocampus - pathology
Humans
Magnetic Resonance Imaging
Medicine
Medicine & Public Health
Neurology
Neuroradiology
Neurosciences
Neurosurgery
Original Article
Patients
Psychiatry
Seizures
Statistical analysis
Temporal lobe
Theta rhythms
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Summary:Objective Cognitive impairment in temporal lobe epilepsy is widely acknowledged as one of the most well-known comorbidities. This study aimed to explore cognitive impairment and to determine the potential clinical, radiological, and quantitative electroencephalography markers for cognitive impairment in temporal lobe epilepsy patients versus extra-temporal lobe epilepsy. Methods Forty-five patients with temporal lobe epilepsy and forty-five patients with extra-temporal lobe epilepsy were recruited for an administered digit span test, verbal fluency test, mini-mental state examination, digital symbol test, and Montreal cognitive assessment. Also, they were subjected to magnetic resonance imaging assessment for hippocampal atrophy and a quantitative electroencephalography assessment for electroencephalography markers (median frequency, peak frequency, and the alpha-to-theta ratio). Results Patients with extra-temporal lobe epilepsy showed non-significant higher epilepsy durations and a higher frequency of seizures. Temporal lobe epilepsy patients showed a more statistically significant family history of epilepsy (37.7%), more history of febrile convulsions (13.3%), higher hippocampal atrophy (17.8%), and lower cognitive scales, especially mini-mental state examination and Montreal cognitive assessment; lower digital symbol test, verbal fluency test, and backward memory of digit span test. Also, temporal lobe epilepsy patients had a strong negative correlation with electroencephalography markers: median frequency, peak frequency, and the alpha-to-theta ratio ( r  =  − 0.68, P  
ISSN:1590-1874
1590-3478
DOI:10.1007/s10072-021-05540-4