Evaluating the mechanisms of action and subcellular localization of ruthenium(II)-based photosensitizers

The identification of ruthenium(II) polypyridyl complexes as photosensitizers in photodynamic therapy (PDT) for the treatment of cancer is progressing rapidly. Due to their favorable photophysical and photochemical properties, Ru(II)-based photosensitizers have absorption in the visible spectrum, ca...

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Bibliographic Details
Published in:European journal of medicinal chemistry 2021-12, Vol.225, p.113770-113770, Article 113770
Main Authors: Mo, Jiancheng, Mai Le, Ngoc Phuong, Priefer, Ronny
Format: Article
Language:English
Subjects:
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Cancer
Cell Proliferation - drug effects
Cell Survival - drug effects
Coordination Complexes - chemistry
Coordination Complexes - pharmacology
Drug Screening Assays, Antitumor
Humans
Molecular Structure
Neoplasms - drug therapy
Neoplasms - pathology
Photochemotherapy
Photodynamic therapy
Photosensitizing Agents - chemistry
Photosensitizing Agents - pharmacology
Ruthenium - chemistry
Ruthenium - pharmacology
Ruthenium(II) photosensitizers
Subcellular localization
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Summary:The identification of ruthenium(II) polypyridyl complexes as photosensitizers in photodynamic therapy (PDT) for the treatment of cancer is progressing rapidly. Due to their favorable photophysical and photochemical properties, Ru(II)-based photosensitizers have absorption in the visible spectrum, can be irradiated via one- and two-photon excitation within the PDT window, and yield potent oxygen-dependent and/or oxygen-independent photobiological activities. Herein, we present a current overview of the mechanisms of action and subcellular localization of Ru(II)-based photosensitizers in the treatment of cancer. These photosensitizers are highlighted from a medicinal chemistry and chemical biology perspective. However, although this field is burgeoning, challenges and limitations remain in the photosensitization strategies and clinical translation. [Display omitted] •Ru(II)-based photosensitizers can localize in different organelles in cancer cells.•They have potent oxygen-dependent and/or -independent photobiological activities.•Future challenges remain in photosensitization strategies and clinical translation.
ISSN:0223-5234
1768-3254
DOI:10.1016/j.ejmech.2021.113770