Acetylcholine receptor antibodies in a patient with sensory neuropathy

Antibodies to acetylcholine receptor (AChR) are detected in the vast majority of patients with generalized myasthenia gravis (MG) and are rarely detected in significant titer in other autoimmune diseases. We report a patient with an axonal predominately sensory neuropathy for over 12 years with pers...

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Bibliographic Details
Published in:Journal of neuroimmunology 2021-10, Vol.359, p.577692-577692, Article 577692
Main Authors: Sriwastava, Shitiz, Lisak, Robert P.
Format: Article
Language:English
Subjects:
Acetylcholine receptor antibodies
Aged
Autoantibodies - blood
Autoantibodies - immunology
Autoimmune disorder
Humans
Male
Myasthenia gravis
Myasthenia Gravis - blood
Myasthenia Gravis - diagnosis
Myasthenia Gravis - immunology
Peripheral Nervous System Diseases - blood
Peripheral Nervous System Diseases - diagnosis
Peripheral Nervous System Diseases - immunology
Receptors, Cholinergic - biosynthesis
Receptors, Cholinergic - immunology
Sensory neuropathy
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Summary:Antibodies to acetylcholine receptor (AChR) are detected in the vast majority of patients with generalized myasthenia gravis (MG) and are rarely detected in significant titer in other autoimmune diseases. We report a patient with an axonal predominately sensory neuropathy for over 12 years with persistent binding and modulating AChR antibodies as well as striational muscle antibodies with no evidence of MG or any neoplastic disease.
ISSN:0165-5728
1872-8421
DOI:10.1016/j.jneuroim.2021.577692