Epstein-Barr virus induced post-transplant lymphoproliferative disorder presenting with unilateral retinal involvement

PURPOSEPost-transplant lymphoproliferative disorder (PTLD) represents a spectrum of disorders associated with Epstein Barr Virus infection in up to 80% of cases in the setting of pharmacologic immunosuppression following hematopoietic stem cell or solid organ transplantation. Ocular involvement is a...

Full description

Saved in:
Bibliographic Details
Published in:American journal of ophthalmology case reports 2021, Vol.23, p.101186-101186
Main Authors: Adam, Mainguy, Elise, Philippakis, Sutra Del Galy, Aurélien, Dinu, Stanescu-Segall, Ramin, Tadayoni, Bahram, Bodaghi, Sophie, Bonnin, Sara, Touhami
Format: Report
Language:English
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:PURPOSEPost-transplant lymphoproliferative disorder (PTLD) represents a spectrum of disorders associated with Epstein Barr Virus infection in up to 80% of cases in the setting of pharmacologic immunosuppression following hematopoietic stem cell or solid organ transplantation. Ocular involvement is a rare finding in PTLD. OBSERVATIONWe report the case of a 38-year-old man who presented with unilateral retinal infiltrates as first manifestation of PTLD relapse. Diagnosis relied on the presence of EBV DNA in anterior chamber fluids and vitrectomy that showed the presence of a B cell clone. Systemic relapse of PTLD was detected 12 weeks after retinal findings. Treatment of ocular disease included systemic injections of rituximab and intravitreal injections of methotrexate, halting the extension of retinal infiltrates. CONCLUSIONOcular involvement in PTLD is rare and needs to be acknowledged because it can precede a systemic relapse of the hematological condition.
ISSN:2451-9936
DOI:10.1016/j.ajoc.2021.101186