Mechanics and self-organization in tissue development

Self-organization is an all-important feature of living systems that provides the means to achieve specialization and functionality at distinct spatio-temporal scales. Herein, we review this concept by addressing the packing organization of cells, the sorting/compartmentalization phenomenon of cell...

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Bibliographic Details
Published in:Seminars in cell & developmental biology 2021-12, Vol.120, p.147-159
Main Authors: Gómez-Gálvez, Pedro, Anbari, Samira, Escudero, Luis M., Buceta, Javier
Format: Article
Language:English
Subjects:
Cell packing
Cell sorting
Developmental mechanics
Developmental mechanisms
Epithelia
ERK
Humans
Morphogenesis - physiology
Self-organization
Signal Transduction
Traveling waves
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Summary:Self-organization is an all-important feature of living systems that provides the means to achieve specialization and functionality at distinct spatio-temporal scales. Herein, we review this concept by addressing the packing organization of cells, the sorting/compartmentalization phenomenon of cell populations, and the propagation of organizing cues at the tissue level through traveling waves. We elaborate on how different theoretical models and tools from Topology, Physics, and Dynamical Systems have improved the understanding of self-organization by shedding light on the role played by mechanics as a driver of morphogenesis. Altogether, by providing a historical perspective, we show how ideas and hypotheses in the field have been revisited, developed, and/or rejected and what are the open questions that need to be tackled by future research.
ISSN:1084-9521
1096-3634
DOI:10.1016/j.semcdb.2021.07.003