Overview of serum and tissue markers in colorectal cancer: a primer for radiologists

Serum and tissue tumor markers provide crucial information in the diagnosis, treatment, and follow-up of colorectal cancers. Tissue tumor markers are increasingly used for determination of targeted chemotherapy planning based on genotyping of tumor cells. Recently, plasma-based technique of liquid b...

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Bibliographic Details
Published in:Abdominal imaging 2021-12, Vol.46 (12), p.5521-5535
Main Authors: Bonde, Apurva, Smith, Daniel A., Kikano, Elias, Yoest, Jennifer M., Tirumani, Sree H., Ramaiya, Nikhil H.
Format: Article
Language:English
Subjects:
Biomarkers
Biomarkers, Tumor
Biopsy
Cancer
Chemotherapy
Colorectal cancer
Colorectal carcinoma
Colorectal Neoplasms - diagnostic imaging
Evaluation
Gastroenterology
Genotypes
Genotyping
Hepatology
Humans
Imaging
Imaging techniques
Liquid Biopsy
Medical diagnosis
Medical imaging
Medicine
Medicine & Public Health
Metastases
Neoplasm Recurrence, Local
Radiologists
Radiology
Review
Tissues
Tumor cells
Tumor markers
Tumors
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Summary:Serum and tissue tumor markers provide crucial information in the diagnosis, treatment, and follow-up of colorectal cancers. Tissue tumor markers are increasingly used for determination of targeted chemotherapy planning based on genotyping of tumor cells. Recently, plasma-based technique of liquid biopsy is being evaluated for providing tumor biomarkers in the management of colorectal cancer. Tumor markers are commonly used in conjunction with imaging during initial staging, treatment determination, response assessment, and determination of recurrence or metastatic disease. Knowledge of tumor markers and their association with radiological findings is thus crucial for radiologists. Additionally, various novel imaging techniques are being evaluated as potential noninvasive imaging biomarkers to predict tumor genotypes, features, and tumor response. We review and discuss the potential role of these newer imaging techniques. Graphic abstract
ISSN:2366-004X
2366-0058
DOI:10.1007/s00261-021-03243-0