Intravascular ultrasound insights into the unstable features of the coronary atherosclerotic plaques: A systematic review and meta‐analysis

Background There is a lack of a comprehensive picture of plaque geometry and composition of unstable atherosclerotic lesions as observed with intravascular ultrasound techniques. We analysed through a systematic review with meta‐analysis 39 characteristics of atherosclerotic plaques in three scenari...

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Bibliographic Details
Published in:European journal of clinical investigation 2022-01, Vol.52 (1), p.e13671-n/a
Main Authors: Homorodean, Calin, Leucuta, Daniel‐Corneliu, Ober, Mihai, Homorodean, Romana, Spinu, Mihail, Olinic, Maria, Tataru, Dan, Olinic, Dan‐Mircea
Format: Article
Language:English
Subjects:
acute coronary syndrome
Acute coronary syndromes
Angina
Angina pectoris
Arteriosclerosis
Atherosclerosis
Cores
Coronary Artery Disease - diagnostic imaging
Disorders
Humans
intravascular ultrasound
Lesions
Lipids
Meta-analysis
non‐culprit lesion
plaque morphology
Plaque, Atherosclerotic - diagnostic imaging
Plaques
Systematic review
Ultrasonic imaging
Ultrasonic methods
Ultrasonic testing
Ultrasonography, Interventional
Ultrasound
vessel remodeling
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Summary:Background There is a lack of a comprehensive picture of plaque geometry and composition of unstable atherosclerotic lesions as observed with intravascular ultrasound techniques. We analysed through a systematic review with meta‐analysis 39 characteristics of atherosclerotic plaques in three scenarios involving culprit and non‐culprit lesions from acute coronary syndromes vs stable angina pectoris patients, and culprit vs non‐culprit lesions in acute coronary syndromes patients. Methods A systematic search of PubMed and EMBASE, from inception to April 2020 was performed. The combined odds ratios or mean differences of all IVUS characteristics were calculated with random‐effects models. Results Twenty‐eight studies involving 5434 subjects, and 5618 lesions were included. Culprit lesions in acute coronary syndromes have larger plaque areas and remodeling indexes (MD = 0.13 [0.08; 0.17], p 
ISSN:0014-2972
1365-2362
DOI:10.1111/eci.13671