LIODetect®TB-ST: Evaluation of novel blood test for a rapid diagnosis of active pulmonary and extra-pulmonary tuberculosis in IGRA confirmed patients

Because of the current limits of immunological tests in the diagnosis of tuberculosis there is a need to identify new and rapid tests that can be carried out on a large scale in endemic countries and useful in the identification of infected subjects, but also able to discriminate those with latent i...

Full description

Saved in:
Bibliographic Details
Published in:Tuberculosis (Edinburgh, Scotland) Scotland), 2021-09, Vol.130, p.102119-102119, Article 102119
Main Authors: La Manna, Marco Pio, Tamburini, Bartolo, Orlando, Valentina, Badami, Giusto Davide, Di Carlo, Paola, Cascio, Antonio, Singh, Mahavir, Dieli, Francesco, Caccamo, Nadia
Format: Article
Language:English
Subjects:
Adult
Antibodies
Antibodies, Bacterial - analysis
Blood
Blood tests
Diagnosis
Female
Hematologic Tests
Humans
IFN-γ
Immunoglobulin A
Immunoglobulin G
Immunoglobulin M
Immunology
Interferon-gamma Release Tests
Latent infection
LIODetect®TB-ST
Male
Middle Aged
Mycobacterium tuberculosis
PLUS
Quantiferon TB Gold
Sensitivity and Specificity
Tuberculosis
Tuberculosis - classification
Tuberculosis - diagnosis
Tuberculosis, Pulmonary - diagnosis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Because of the current limits of immunological tests in the diagnosis of tuberculosis there is a need to identify new and rapid tests that can be carried out on a large scale in endemic countries and useful in the identification of infected subjects, but also able to discriminate those with latent infection from subjects with active. We have taken into consideration and analysed the LIODetect®TB-ST Tuberculosis Rapid Test, a membrane test for the qualitative detection of specific IgG, IgA, and IgM antibodies against Mycobacterium tuberculosis, performed on serum, plasma, or whole blood.85 samples positive to QuantiFERON TB-GOLD PLUS test were processed using this test and the results obtained were concordant with clinical diagnosis.To our knowledge, the LIODetect®TB-ST Tuberculosis Rapid Test is the only test; that identifies active tuberculosis disease with high sensitivity and specificity and its use might be of help in the diagnosis of tuberculosis, especially in endemic countries.
ISSN:1472-9792
1873-281X
DOI:10.1016/j.tube.2021.102119