Opioid Use as a Predictor of Pain Outcomes in Iraq and Afghanistan Veterans with Chronic Pain: Analysis of a Randomized Controlled Trial

Abstract Objective Our objectives were to: 1) assess the relationship between self-reported opioid use and baseline demographics, clinical characteristics and pain outcomes; and 2) examine whether baseline opioid use moderated the intervention effect on outcomes at 9 months. Design We conducted a se...

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Bibliographic Details
Published in:Pain medicine (Malden, Mass.) Mass.), 2021-12, Vol.22 (12), p.2964-2970
Main Authors: Bushey, Michael A, Wu, Jingwei, Outcalt, Samantha D, Krebs, Erin E, Ang, Dennis, Kline, Matthew, Yu, Zhangsheng, Bair, Matthew J
Format: Article
Language:English
Subjects:
Afghanistan
Analgesics, Opioid - therapeutic use
Chronic pain
Chronic Pain - drug therapy
Drug therapy
Humans
Iraq
Narcotics
Opioids
Patient outcomes
Patients
Veterans
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Summary:Abstract Objective Our objectives were to: 1) assess the relationship between self-reported opioid use and baseline demographics, clinical characteristics and pain outcomes; and 2) examine whether baseline opioid use moderated the intervention effect on outcomes at 9 months. Design We conducted a secondary analysis of data from the Evaluation of Stepped Care for Chronic Pain (ESCAPE) trial, which found stepped-care to be effective for chronic pain in military veterans. Setting A post-deployment clinic and five general medicine clinics at a Veteran Affairs Medical Center. Subjects In total 241 veterans with chronic musculoskeletal pain; 220 with complete data at 9 months. Methods Examination of baseline relationships and multivariable linear regression to examine baseline opioid use as a moderator of pain-related outcomes including Roland Morris Disability Questionnaire (RMDQ), Brief Pain Inventory (BPI) Interference scale, and Graded Chronic Pain Scale (GCPS) at 9 months. Results Veterans reporting baseline opioid use (n = 80) had significantly worse RMDQ (16.0 ± 4.9 vs. 13.4 ± 4.2, P 
ISSN:1526-2375
1526-4637
DOI:10.1093/pm/pnab237