Paramyxoviruses from neotropical bats suggest a novel genus and nephrotropism

Paramyxoviruses have a broad host range and geographic distribution, including human pathogens transmitted by bats, such as Nipah and Hendra viruses. In this study, we combined high-throughput sequencing and molecular approaches to investigate the presence of paramyxoviruses in neotropical bats (Mic...

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Published in:Infection, genetics and evolution genetics and evolution, 2021-11, Vol.95, p.105041-105041, Article 105041
Main Authors: de Souza, William Marciel, Fumagalli, Marcilio Jorge, Carrera, Jean Paul, de Araujo, Jansen, Cardoso, Jedson Ferreira, de Carvalho, Cristiano, Durigon, Edison Luiz, Queiroz, Luzia Helena, Faria, Nuno Rodrigues, Murcia, Pablo R., Figueiredo, Luiz Tadeu Moraes
Format: Article
Language:English
Subjects:
Animals
Bat-borne diseases
Brazil - epidemiology
Chiroptera
Host Specificity
Paramyxoviridae
Paramyxoviridae - classification
Paramyxoviridae - physiology
Paramyxoviridae Infections - veterinary
Paramyxovirus
Phylogeny
Prevalence
RNA, Viral - analysis
Virus discovery
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Summary:Paramyxoviruses have a broad host range and geographic distribution, including human pathogens transmitted by bats, such as Nipah and Hendra viruses. In this study, we combined high-throughput sequencing and molecular approaches to investigate the presence of paramyxoviruses in neotropical bats (Microchiroptera suborder) in Brazil. We discovered and characterized three novel paramyxoviruses in the kidney tissues of apparently healthy common vampire bats (D. rotundus) and Seba's short-tailed bats (C. perspicillata), which we tentatively named Kanhgág virus (KANV), Boe virus (BOEV), and Guató virus (GUATV). In this study, we classified these viruses as putative species into the Macrojêvirus genus, a newly proposed genus of the Orthoparamyxovirinae subfamily. Using RT-PCR, we detected these viruses in 20.9% (9 out of 43) of bats tested, and viral RNA was detected exclusively in kidney tissues. Attempts to isolate infectious virus were successful for KANV and GUATV. Our results expand the viral diversity, host range, and geographical distribution of the paramyxoviruses. •Discovery and characterization of three novel paramyxoviruses in neotropical bats.•Identification of Macrojêvirus genus, a newly proposed genus into the Orthoparamyxovirinae subfamily.•Novel paramyxoviruses viral were detected exclusively in kidney tissues.
ISSN:1567-1348
1567-7257
DOI:10.1016/j.meegid.2021.105041