Potential of nanoparticulate based delivery systems for effective management of alopecia

• Published in: Colloids and surfaces, B, Biointerfaces B, Biointerfaces, 2021-12, Vol.208, p.112050-112050, Article 112050
• Main Authors: Mishra, Priya, Handa, Mayank, Ujjwal, Rewati R., Singh, Vanshikha, Kesharwani, Prashant, Shukla, Rahul
• Format: Article
• Language: English
• Subjects: Alopecia; Hair; Minoxidil; Nanomedicine; Nanotoxicity; Preclinical; Topical delivery
• ISSN: 0927-7765; 1873-4367
• DOI: 10.1016/j.colsurfb.2021.112050

[Display omitted] •Nanocarriers used to overcome limitations of conventional therapies have been discussed.•Comparative studies on these nanocarriers have covered for understanding their efficacy.•Role of nano-drug delivery in the management of alopecia has been also summarized. In recent times, more than 50 % of the global population is facing hair-related issues (alopecia) which is seen mostly amongst the people in the age group of 30–40 years. The conventional topical dosage forms available in the market falls short in effectively managing alopecia. Despite various advancements in topical dosage forms, it is still disposed to limited clinical application and provides poor penetration of drug molecules into the skin. The exact etiology of alopecia is still unknown and various researchers link lifestyle, hereditary, and auto immune-based events with its existence. Nanoparticulate-based delivery are hence brought in use to enhance the permeability properties of the drug. In comparison to conventional methods nanotechnology-based drug delivery system tames drug molecules to a specific site with much better efficacy. This review is engrossed in the journey and role of nano technological-based drug delivery in the management of alopecia and its clinical application.