Adjuvant and post-surgical treatment in endometrial cancer

Endometrial cancer (EC) usually presented as a localized disease at diagnosis (67%), 20% of patients diagnosed with regional spread, and distant metastasis accounted for 9%. The standard treatments include hysterectomy, bilateral salpingo-oophorectomy, and pelvic with/without paraaortic lymph node d...

Full description

Saved in:
Bibliographic Details
Published in:Best practice & research. Clinical obstetrics & gynaecology 2022-01, Vol.78, p.52-63
Main Authors: Tung, Hsiu-Jung, Huang, Huei-Jean, Lai, Chyong-Huey
Format: Article
Language:English
Subjects:
Adjuvant therapy
Chemotherapy, Adjuvant
Endometrial cancer
Endometrial Neoplasms - surgery
Female
Humans
Hysterectomy
Lymph Node Excision
Lymphatic Metastasis
Neoplasm Staging
Primary staging surgery
Radiotherapy, Adjuvant
Retrospective Studies
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Endometrial cancer (EC) usually presented as a localized disease at diagnosis (67%), 20% of patients diagnosed with regional spread, and distant metastasis accounted for 9%. The standard treatments include hysterectomy, bilateral salpingo-oophorectomy, and pelvic with/without paraaortic lymph node dissection/biopsy. Adjuvant therapy is arranged according to risk factors and stages. Risk group classification varied among different guidelines and studies and evolved with time. Adjuvant modalities include chemotherapy, radiotherapy, chemoradiotherapy, antiangiogenesis agents, immune checkpoint inhibitors, and multi-target agents. We review the recent literature to incorporate important advances in trial results, real-world big data, and knowledge in biomarkers of EC to update appropriate adjuvant therapy and post-surgical treatment of EC patients.
ISSN:1521-6934
1532-1932
DOI:10.1016/j.bpobgyn.2021.06.002