Loading…
Incidence of and risk factors for spondylolisthesis, scoliosis, and vertebral fracture in rheumatoid arthritis
Introduction Although lumbar lesions such as spondylolisthesis, scoliosis, and vertebral fracture are not specific to rheumatoid arthritis (RA), the prevalence is high in RA patients. However, no longitudinal study has evaluated lumbar lesions in RA. This study aimed to investigate the incidence of...
Saved in:
Published in: | Journal of bone and mineral metabolism 2022-01, Vol.40 (1), p.120-131 |
---|---|
Main Authors: | , , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
cited_by | cdi_FETCH-LOGICAL-c465t-815c0ba416f8a40eeb96ec43076e589e1af8d36fc4c786d78952960bb7a264d63 |
---|---|
cites | cdi_FETCH-LOGICAL-c465t-815c0ba416f8a40eeb96ec43076e589e1af8d36fc4c786d78952960bb7a264d63 |
container_end_page | 131 |
container_issue | 1 |
container_start_page | 120 |
container_title | Journal of bone and mineral metabolism |
container_volume | 40 |
creator | Yamada, Kentaro Suzuki, Akinobu Takahashi, Shinji Inui, Kentaro Koike, Tatsuya Okano, Tadashi Yabu, Akito Hori, Yusuke Toyoda, Hiromitsu Nakamura, Hiroaki |
description | Introduction
Although lumbar lesions such as spondylolisthesis, scoliosis, and vertebral fracture are not specific to rheumatoid arthritis (RA), the prevalence is high in RA patients. However, no longitudinal study has evaluated lumbar lesions in RA. This study aimed to investigate the incidence of and risk factors for lumbar lesions in RA by a prospective longitudinal cohort study.
Materials and methods
The study cohort comprised 110 patients with RA from the ‘analysis of factors for RA spinal disorders (AFFORD)’ study who completed the secondary survey at a single orthopaedic outpatient RA clinic. Radiological examination included standing radiographs and magnetic resonance imaging (MRI) of the lumbar spine. New development of spondylolisthesis, scoliosis, and vertebral fracture were assessed between baseline and secondary survey.
Results
The incidences of spondylolisthesis, scoliosis, and vertebral fracture were 42%, 16%, and 12%, respectively, during a mean follow-up of 7 years. The independent risk factor for de novo scoliosis was poor control of RA (adjusted odds ratio [aOR] 4.81,
p
= 0.011), while the independent risk factors for new vertebral fracture was use of glucocorticoid at secondary survey (aOR 14.87,
p
= 0.012). Patients with de novo scoliosis exhibited more severe low back pain and lower quality of life than those without.
Conclusion
The incidence of scoliosis was related in patients with poor control of RA, while new vertebral fracture was more common in patients with use of glucocorticoid. Control of disease activity might be important in preventing radiological lumbar disorders in RA. |
doi_str_mv | 10.1007/s00774-021-01261-y |
format | article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2563718641</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2563718641</sourcerecordid><originalsourceid>FETCH-LOGICAL-c465t-815c0ba416f8a40eeb96ec43076e589e1af8d36fc4c786d78952960bb7a264d63</originalsourceid><addsrcrecordid>eNp9kUtv1DAUhS0EotOBP8ACWWLDgoCd-JEsUQW0UiU2sLYc55pxydjDvQnS_Hs8nQISCzZ-yN851zqHsRdSvJVC2HdUF6sa0cpGyNbI5viIbaTqdKONUI_ZRgxSNb21wwW7JLoTQlpt5VN20SnVKiW7Dcs3OaQJcgBeIvd54pjoO48-LAWJx4KcDiVPx7nMiZYdUKI3nEK9lfvjSfITcIER_cwjVuGKwFPmuIN175eSJu5x2WFaEj1jT6KfCZ4_7Fv29eOHL1fXze3nTzdX72-boIxeml7qIEavpIm9VwJgHAwE1QlrQPcDSB_7qTMxqGB7M9l-0O1gxDha3xo1mW7LXp99D1h-rECL2ycKMM8-Q1nJtdp0VvamZrBlr_5B78qKuf7O1UyHwahWn6j2TAUsRAjRHTDtPR6dFO7Uhju34Wob7r4Nd6yilw_W67iH6Y_kd_wV6M4A1af8DfDv7P_Y_gKXFJa-</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2619964251</pqid></control><display><type>article</type><title>Incidence of and risk factors for spondylolisthesis, scoliosis, and vertebral fracture in rheumatoid arthritis</title><source>Springer Link</source><creator>Yamada, Kentaro ; Suzuki, Akinobu ; Takahashi, Shinji ; Inui, Kentaro ; Koike, Tatsuya ; Okano, Tadashi ; Yabu, Akito ; Hori, Yusuke ; Toyoda, Hiromitsu ; Nakamura, Hiroaki</creator><creatorcontrib>Yamada, Kentaro ; Suzuki, Akinobu ; Takahashi, Shinji ; Inui, Kentaro ; Koike, Tatsuya ; Okano, Tadashi ; Yabu, Akito ; Hori, Yusuke ; Toyoda, Hiromitsu ; Nakamura, Hiroaki</creatorcontrib><description>Introduction
Although lumbar lesions such as spondylolisthesis, scoliosis, and vertebral fracture are not specific to rheumatoid arthritis (RA), the prevalence is high in RA patients. However, no longitudinal study has evaluated lumbar lesions in RA. This study aimed to investigate the incidence of and risk factors for lumbar lesions in RA by a prospective longitudinal cohort study.
Materials and methods
The study cohort comprised 110 patients with RA from the ‘analysis of factors for RA spinal disorders (AFFORD)’ study who completed the secondary survey at a single orthopaedic outpatient RA clinic. Radiological examination included standing radiographs and magnetic resonance imaging (MRI) of the lumbar spine. New development of spondylolisthesis, scoliosis, and vertebral fracture were assessed between baseline and secondary survey.
Results
The incidences of spondylolisthesis, scoliosis, and vertebral fracture were 42%, 16%, and 12%, respectively, during a mean follow-up of 7 years. The independent risk factor for de novo scoliosis was poor control of RA (adjusted odds ratio [aOR] 4.81,
p
= 0.011), while the independent risk factors for new vertebral fracture was use of glucocorticoid at secondary survey (aOR 14.87,
p
= 0.012). Patients with de novo scoliosis exhibited more severe low back pain and lower quality of life than those without.
Conclusion
The incidence of scoliosis was related in patients with poor control of RA, while new vertebral fracture was more common in patients with use of glucocorticoid. Control of disease activity might be important in preventing radiological lumbar disorders in RA.</description><identifier>ISSN: 0914-8779</identifier><identifier>EISSN: 1435-5604</identifier><identifier>DOI: 10.1007/s00774-021-01261-y</identifier><identifier>PMID: 34424413</identifier><language>eng</language><publisher>Singapore: Springer Singapore</publisher><subject>Arthritis, Rheumatoid - complications ; Arthritis, Rheumatoid - epidemiology ; Glucocorticoids ; Humans ; Incidence ; Lesions ; Longitudinal Studies ; Low back pain ; Lumbar Vertebrae - diagnostic imaging ; Magnetic resonance imaging ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Original Article ; Orthopedics ; Prospective Studies ; Quality of Life ; Rheumatoid arthritis ; Risk Factors ; Scoliosis ; Scoliosis - diagnostic imaging ; Scoliosis - epidemiology ; Spinal Fractures - diagnostic imaging ; Spinal Fractures - epidemiology ; Spine (lumbar) ; Spondylolisthesis ; Spondylolisthesis - diagnostic imaging ; Spondylolisthesis - epidemiology ; Vertebrae</subject><ispartof>Journal of bone and mineral metabolism, 2022-01, Vol.40 (1), p.120-131</ispartof><rights>The Japanese Society Bone and Mineral Research 2021</rights><rights>2021. The Japanese Society Bone and Mineral Research.</rights><rights>The Japanese Society Bone and Mineral Research 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c465t-815c0ba416f8a40eeb96ec43076e589e1af8d36fc4c786d78952960bb7a264d63</citedby><cites>FETCH-LOGICAL-c465t-815c0ba416f8a40eeb96ec43076e589e1af8d36fc4c786d78952960bb7a264d63</cites><orcidid>0000-0001-9864-2017</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34424413$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yamada, Kentaro</creatorcontrib><creatorcontrib>Suzuki, Akinobu</creatorcontrib><creatorcontrib>Takahashi, Shinji</creatorcontrib><creatorcontrib>Inui, Kentaro</creatorcontrib><creatorcontrib>Koike, Tatsuya</creatorcontrib><creatorcontrib>Okano, Tadashi</creatorcontrib><creatorcontrib>Yabu, Akito</creatorcontrib><creatorcontrib>Hori, Yusuke</creatorcontrib><creatorcontrib>Toyoda, Hiromitsu</creatorcontrib><creatorcontrib>Nakamura, Hiroaki</creatorcontrib><title>Incidence of and risk factors for spondylolisthesis, scoliosis, and vertebral fracture in rheumatoid arthritis</title><title>Journal of bone and mineral metabolism</title><addtitle>J Bone Miner Metab</addtitle><addtitle>J Bone Miner Metab</addtitle><description>Introduction
Although lumbar lesions such as spondylolisthesis, scoliosis, and vertebral fracture are not specific to rheumatoid arthritis (RA), the prevalence is high in RA patients. However, no longitudinal study has evaluated lumbar lesions in RA. This study aimed to investigate the incidence of and risk factors for lumbar lesions in RA by a prospective longitudinal cohort study.
Materials and methods
The study cohort comprised 110 patients with RA from the ‘analysis of factors for RA spinal disorders (AFFORD)’ study who completed the secondary survey at a single orthopaedic outpatient RA clinic. Radiological examination included standing radiographs and magnetic resonance imaging (MRI) of the lumbar spine. New development of spondylolisthesis, scoliosis, and vertebral fracture were assessed between baseline and secondary survey.
Results
The incidences of spondylolisthesis, scoliosis, and vertebral fracture were 42%, 16%, and 12%, respectively, during a mean follow-up of 7 years. The independent risk factor for de novo scoliosis was poor control of RA (adjusted odds ratio [aOR] 4.81,
p
= 0.011), while the independent risk factors for new vertebral fracture was use of glucocorticoid at secondary survey (aOR 14.87,
p
= 0.012). Patients with de novo scoliosis exhibited more severe low back pain and lower quality of life than those without.
Conclusion
The incidence of scoliosis was related in patients with poor control of RA, while new vertebral fracture was more common in patients with use of glucocorticoid. Control of disease activity might be important in preventing radiological lumbar disorders in RA.</description><subject>Arthritis, Rheumatoid - complications</subject><subject>Arthritis, Rheumatoid - epidemiology</subject><subject>Glucocorticoids</subject><subject>Humans</subject><subject>Incidence</subject><subject>Lesions</subject><subject>Longitudinal Studies</subject><subject>Low back pain</subject><subject>Lumbar Vertebrae - diagnostic imaging</subject><subject>Magnetic resonance imaging</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Original Article</subject><subject>Orthopedics</subject><subject>Prospective Studies</subject><subject>Quality of Life</subject><subject>Rheumatoid arthritis</subject><subject>Risk Factors</subject><subject>Scoliosis</subject><subject>Scoliosis - diagnostic imaging</subject><subject>Scoliosis - epidemiology</subject><subject>Spinal Fractures - diagnostic imaging</subject><subject>Spinal Fractures - epidemiology</subject><subject>Spine (lumbar)</subject><subject>Spondylolisthesis</subject><subject>Spondylolisthesis - diagnostic imaging</subject><subject>Spondylolisthesis - epidemiology</subject><subject>Vertebrae</subject><issn>0914-8779</issn><issn>1435-5604</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9kUtv1DAUhS0EotOBP8ACWWLDgoCd-JEsUQW0UiU2sLYc55pxydjDvQnS_Hs8nQISCzZ-yN851zqHsRdSvJVC2HdUF6sa0cpGyNbI5viIbaTqdKONUI_ZRgxSNb21wwW7JLoTQlpt5VN20SnVKiW7Dcs3OaQJcgBeIvd54pjoO48-LAWJx4KcDiVPx7nMiZYdUKI3nEK9lfvjSfITcIER_cwjVuGKwFPmuIN175eSJu5x2WFaEj1jT6KfCZ4_7Fv29eOHL1fXze3nTzdX72-boIxeml7qIEavpIm9VwJgHAwE1QlrQPcDSB_7qTMxqGB7M9l-0O1gxDha3xo1mW7LXp99D1h-rECL2ycKMM8-Q1nJtdp0VvamZrBlr_5B78qKuf7O1UyHwahWn6j2TAUsRAjRHTDtPR6dFO7Uhju34Wob7r4Nd6yilw_W67iH6Y_kd_wV6M4A1af8DfDv7P_Y_gKXFJa-</recordid><startdate>20220101</startdate><enddate>20220101</enddate><creator>Yamada, Kentaro</creator><creator>Suzuki, Akinobu</creator><creator>Takahashi, Shinji</creator><creator>Inui, Kentaro</creator><creator>Koike, Tatsuya</creator><creator>Okano, Tadashi</creator><creator>Yabu, Akito</creator><creator>Hori, Yusuke</creator><creator>Toyoda, Hiromitsu</creator><creator>Nakamura, Hiroaki</creator><general>Springer Singapore</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-9864-2017</orcidid></search><sort><creationdate>20220101</creationdate><title>Incidence of and risk factors for spondylolisthesis, scoliosis, and vertebral fracture in rheumatoid arthritis</title><author>Yamada, Kentaro ; Suzuki, Akinobu ; Takahashi, Shinji ; Inui, Kentaro ; Koike, Tatsuya ; Okano, Tadashi ; Yabu, Akito ; Hori, Yusuke ; Toyoda, Hiromitsu ; Nakamura, Hiroaki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c465t-815c0ba416f8a40eeb96ec43076e589e1af8d36fc4c786d78952960bb7a264d63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Arthritis, Rheumatoid - complications</topic><topic>Arthritis, Rheumatoid - epidemiology</topic><topic>Glucocorticoids</topic><topic>Humans</topic><topic>Incidence</topic><topic>Lesions</topic><topic>Longitudinal Studies</topic><topic>Low back pain</topic><topic>Lumbar Vertebrae - diagnostic imaging</topic><topic>Magnetic resonance imaging</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic Diseases</topic><topic>Original Article</topic><topic>Orthopedics</topic><topic>Prospective Studies</topic><topic>Quality of Life</topic><topic>Rheumatoid arthritis</topic><topic>Risk Factors</topic><topic>Scoliosis</topic><topic>Scoliosis - diagnostic imaging</topic><topic>Scoliosis - epidemiology</topic><topic>Spinal Fractures - diagnostic imaging</topic><topic>Spinal Fractures - epidemiology</topic><topic>Spine (lumbar)</topic><topic>Spondylolisthesis</topic><topic>Spondylolisthesis - diagnostic imaging</topic><topic>Spondylolisthesis - epidemiology</topic><topic>Vertebrae</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yamada, Kentaro</creatorcontrib><creatorcontrib>Suzuki, Akinobu</creatorcontrib><creatorcontrib>Takahashi, Shinji</creatorcontrib><creatorcontrib>Inui, Kentaro</creatorcontrib><creatorcontrib>Koike, Tatsuya</creatorcontrib><creatorcontrib>Okano, Tadashi</creatorcontrib><creatorcontrib>Yabu, Akito</creatorcontrib><creatorcontrib>Hori, Yusuke</creatorcontrib><creatorcontrib>Toyoda, Hiromitsu</creatorcontrib><creatorcontrib>Nakamura, Hiroaki</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Nursing and Allied Health Source</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of bone and mineral metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yamada, Kentaro</au><au>Suzuki, Akinobu</au><au>Takahashi, Shinji</au><au>Inui, Kentaro</au><au>Koike, Tatsuya</au><au>Okano, Tadashi</au><au>Yabu, Akito</au><au>Hori, Yusuke</au><au>Toyoda, Hiromitsu</au><au>Nakamura, Hiroaki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Incidence of and risk factors for spondylolisthesis, scoliosis, and vertebral fracture in rheumatoid arthritis</atitle><jtitle>Journal of bone and mineral metabolism</jtitle><stitle>J Bone Miner Metab</stitle><addtitle>J Bone Miner Metab</addtitle><date>2022-01-01</date><risdate>2022</risdate><volume>40</volume><issue>1</issue><spage>120</spage><epage>131</epage><pages>120-131</pages><issn>0914-8779</issn><eissn>1435-5604</eissn><abstract>Introduction
Although lumbar lesions such as spondylolisthesis, scoliosis, and vertebral fracture are not specific to rheumatoid arthritis (RA), the prevalence is high in RA patients. However, no longitudinal study has evaluated lumbar lesions in RA. This study aimed to investigate the incidence of and risk factors for lumbar lesions in RA by a prospective longitudinal cohort study.
Materials and methods
The study cohort comprised 110 patients with RA from the ‘analysis of factors for RA spinal disorders (AFFORD)’ study who completed the secondary survey at a single orthopaedic outpatient RA clinic. Radiological examination included standing radiographs and magnetic resonance imaging (MRI) of the lumbar spine. New development of spondylolisthesis, scoliosis, and vertebral fracture were assessed between baseline and secondary survey.
Results
The incidences of spondylolisthesis, scoliosis, and vertebral fracture were 42%, 16%, and 12%, respectively, during a mean follow-up of 7 years. The independent risk factor for de novo scoliosis was poor control of RA (adjusted odds ratio [aOR] 4.81,
p
= 0.011), while the independent risk factors for new vertebral fracture was use of glucocorticoid at secondary survey (aOR 14.87,
p
= 0.012). Patients with de novo scoliosis exhibited more severe low back pain and lower quality of life than those without.
Conclusion
The incidence of scoliosis was related in patients with poor control of RA, while new vertebral fracture was more common in patients with use of glucocorticoid. Control of disease activity might be important in preventing radiological lumbar disorders in RA.</abstract><cop>Singapore</cop><pub>Springer Singapore</pub><pmid>34424413</pmid><doi>10.1007/s00774-021-01261-y</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0001-9864-2017</orcidid></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0914-8779 |
ispartof | Journal of bone and mineral metabolism, 2022-01, Vol.40 (1), p.120-131 |
issn | 0914-8779 1435-5604 |
language | eng |
recordid | cdi_proquest_miscellaneous_2563718641 |
source | Springer Link |
subjects | Arthritis, Rheumatoid - complications Arthritis, Rheumatoid - epidemiology Glucocorticoids Humans Incidence Lesions Longitudinal Studies Low back pain Lumbar Vertebrae - diagnostic imaging Magnetic resonance imaging Medicine Medicine & Public Health Metabolic Diseases Original Article Orthopedics Prospective Studies Quality of Life Rheumatoid arthritis Risk Factors Scoliosis Scoliosis - diagnostic imaging Scoliosis - epidemiology Spinal Fractures - diagnostic imaging Spinal Fractures - epidemiology Spine (lumbar) Spondylolisthesis Spondylolisthesis - diagnostic imaging Spondylolisthesis - epidemiology Vertebrae |
title | Incidence of and risk factors for spondylolisthesis, scoliosis, and vertebral fracture in rheumatoid arthritis |
url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T15%3A26%3A23IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Incidence%20of%20and%20risk%20factors%20for%20spondylolisthesis,%20scoliosis,%20and%20vertebral%20fracture%20in%20rheumatoid%20arthritis&rft.jtitle=Journal%20of%20bone%20and%20mineral%20metabolism&rft.au=Yamada,%20Kentaro&rft.date=2022-01-01&rft.volume=40&rft.issue=1&rft.spage=120&rft.epage=131&rft.pages=120-131&rft.issn=0914-8779&rft.eissn=1435-5604&rft_id=info:doi/10.1007/s00774-021-01261-y&rft_dat=%3Cproquest_cross%3E2563718641%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c465t-815c0ba416f8a40eeb96ec43076e589e1af8d36fc4c786d78952960bb7a264d63%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2619964251&rft_id=info:pmid/34424413&rfr_iscdi=true |