Development of a microcomputer program for statistical evaluation of potential pharmacokinetic drug interactions

A simple and self-explanatory program in BASIC for the statistical evaluation of potential pharmacokinetic drug interactions is described. This program, using the data (times and drug concentrations) obtained from two different populations, and with the help of graphic computing techniques, allows t...

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Bibliographic Details
Published in:Journal of pharmaceutical and biomedical analysis 1990, Vol.8 (8), p.749-753
Main Authors: Soto-Otero, R., Mendez-Alvarez, E., Otero-Cepeda, J.L.
Format: Article
Language:English
Subjects:
Biological and medical sciences
drug interaction
Drug Interactions
drugs
General pharmacology
Medical sciences
Microcomputer program
Microcomputers
Models, Biological
Pharmacokinetics
Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions
Pharmacology. Drug treatments
Software
statistical analysis
Statistics as Topic
Citations: Items that this one cites
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Description
Summary:A simple and self-explanatory program in BASIC for the statistical evaluation of potential pharmacokinetic drug interactions is described. This program, using the data (times and drug concentrations) obtained from two different populations, and with the help of graphic computing techniques, allows the determination and statistical comparison of pharmacokinetic parameters (disposition constants, transfer rate constants, area under the concentration—time curves, etc.) for one- and two-compartment open models after intravenous or extravasal administration. The program is organized in subroutines so that it can be easily modified or extended to other pharmacokinetic models by the user.
ISSN:0731-7085
1873-264X
DOI:10.1016/0731-7085(90)80116-7