The role of Wnt signaling in skin fibrosis

Skin fibrosis is the excessive deposition of extracellular matrix in the dermis. Cutaneous fibrosis can occur following tissue injury, including burns, trauma, and surgery, resulting in scars that are disfiguring, limit movement and cause significant psychological distress for patients. Many molecul...

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Bibliographic Details
Published in:Medicinal research reviews 2022-01, Vol.42 (1), p.615-628
Main Authors: Griffin, Michelle F., Huber, Julika, Evan, Fahy J., Quarto, Natalina, Longaker, Michael T.
Format: Article
Language:English
Subjects:
dermal fibrosis
Extracellular matrix
fibroblast heterogeneity
Signal transduction
Skin diseases
wnt inhibitors
Wnt signaling
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Summary:Skin fibrosis is the excessive deposition of extracellular matrix in the dermis. Cutaneous fibrosis can occur following tissue injury, including burns, trauma, and surgery, resulting in scars that are disfiguring, limit movement and cause significant psychological distress for patients. Many molecular pathways have been implicated in the development of skin fibrosis, yet effective treatments to prevent or reverse scarring are unknown. The Wnt signaling pathways are known to play an important role in skin homeostasis, skin injury, and in the development of fibrotic skin diseases. This review provides a detailed overview of the role of the canonical Wnt signaling pathways in regulating skin scarring. We also discuss how Wnt signaling interacts with other known fibrotic molecular pathways to cause skin fibrosis. We further provide a summary of the different Wnt inhibitor types available for treating skin scarring. Understanding the role of the Wnt pathway in cutaneous fibrosis will accelerate the development of effective Wnt modulators for the treatment of skin fibrosis.
ISSN:0198-6325
1098-1128
DOI:10.1002/med.21853