HFIP-Catalyzed Difluoroalkylation of Propargylic Alcohols to Access Tetrasubstituted Difluoroalkyl Allenes

A hexafluoroisopropanol (HFIP)-catalyzed difluoroalkylation of propargylic alcohols with difluoroenoxysilanes to access structurally diverse tetrasubstituted difluoroalkyl allenes has been developed. This convenient procedure enables the rapid construction of highly functionalized multisubstituted f...

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Bibliographic Details
Published in:Organic letters 2021-09, Vol.23 (18), p.7264-7269
Main Authors: Li, Jinshan, Xi, Wenxue, Liu, Saimei, Ruan, Chenxi, Zheng, Xiaochun, Yang, Jianguo, Wang, Lei, Wang, Zhiming
Format: Article
Language:English
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Summary:A hexafluoroisopropanol (HFIP)-catalyzed difluoroalkylation of propargylic alcohols with difluoroenoxysilanes to access structurally diverse tetrasubstituted difluoroalkyl allenes has been developed. This convenient procedure enables the rapid construction of highly functionalized multisubstituted fluorinated allenes in a mild and straightforward way. Furthermore, the synthetic potential of this methodology has been demonstrated by the facile synthesis of various structurally interesting fluorine-containing molecules such as gem-difluorosubstituted dihydropyran, tetrasubstituted CF2H-allene, and multisubstituted fluorinated cyclopentanone derivatives.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.1c02659