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Relevance of perimarginal nodes for head and neck cancer

Objective To estimate the prevalence of metastasis in the perimarginal nodes (PMNs) (also known as perifacial, preglandular and retroglandual nodes) in head and neck cancer. Methods We recruited 136 patients affected by cancers of the oral cavity, lip, oropharynx, skin and by cáncer of unknown prima...

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Bibliographic Details
Published in:European archives of oto-rhino-laryngology 2022-05, Vol.279 (5), p.2603-2609
Main Authors: Tirelli, Giancarlo, Bussani, Rossana, Marchiori, Virginia, Gardenal, Nicoletta, Boscolo-Rizzo, Paolo, Marcuzzo, Alberto Vito
Format: Article
Language:English
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Summary:Objective To estimate the prevalence of metastasis in the perimarginal nodes (PMNs) (also known as perifacial, preglandular and retroglandual nodes) in head and neck cancer. Methods We recruited 136 patients affected by cancers of the oral cavity, lip, oropharynx, skin and by cáncer of unknown primary (CUP), who were candidates for level IB dissection. PMNs were identified and sent separately for histological analysis. Correlation between metastasis to the PMNs and characteristics of the primary tumour were reported. Results The incidence of metastasis was 17% from oral cancer, 50% from lip cancer and 12.5% from skin cancer. No metastases were reported for oropharynx cancer or CUP. The only factor that correlated with the incidence of metastases was origin of the tumour from the upper part of oral cavity. Conclusion PMNs represent a frequent site of metastasis in oral and lip cancers. In cancer of the oropharynx, their involvement has not been not reported, while their role in skin cancers remains to be clarified.
ISSN:0937-4477
1434-4726
DOI:10.1007/s00405-021-07056-1