Methyltransferase-like protein 11A promotes migration of cervical cancer cells via up-regulating ELK3

• Published in: Pharmacological research 2021-10, Vol.172, p.105814-105814, Article 105814
• Main Authors: Zhang, Jinling, Song, Huibin, Chen, Chen, Chen, Lipeng, Dai, Yong, Sun, Ping-Hui, Zou, Chang, Wang, Xiaoyu
• Format: Article
• Language: English
• Subjects: Animals; Cell Line, Tumor; Cell migration; Cell Movement; Cell Proliferation; Cervical cancer; ELK3; Female; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; Methyltransferases - genetics; Methyltransferases - metabolism; METTL11A; Mice; Proto-Oncogene Proteins c-ets - genetics; Up-Regulation; Uterine Cervical Neoplasms - genetics; Uterine Cervical Neoplasms - metabolism; Uterine Cervical Neoplasms - pathology; Wound Healing
• ISSN: 1043-6618; 1096-1186
• DOI: 10.1016/j.phrs.2021.105814

Cervical cancer is one of the common malignancies in women, which is characterized with high invasion and metastatic tendency in its advanced stage. Increasing evidence indicates that methyltransferase-like (METTL) gene family is involved in the progression of various cancers. However, the functional role of methyltransferase-like gene family in cervical cancer remains unclear. In the present study, we found that METTL11A, a member of the methyltransferase-like gene family, was significantly over-expressed in cervical carcinoma by analyzing TCGA database. This finding was further validated in clinical tissue samples. Moreover, ectopic expression of METTL11A in cervical cancer cell lines promoted cell proliferation and migration both in vitro and in vivo. Differential gene expression analysis in the transcriptomic sequencing data indicated that ELK3 was down-regulated in METTL11A-silenced cervical cancer cells, which was further verified at both protein and mRNA levels. Functional experiments identified that METTL11A promoted migration of cervical cancer cells in an ELK3-dependent manner. This study will promote understanding the mechanism of cervical cancer progression and the functional role of methyltransferase-like gene families in cancers. [Display omitted] •METTL11A is positively correlated with progression of cervical cancer.•METTL11A serves as a potential target for the diagnosis and prognosis of cervical cancer.•METTL11A significantly promotes cell proliferation and cell migration both in vivo and in vitro.•METTL11A promotes the migration of cervical cancer cells by up-regulating ELK3.