Emergence of repurposed drugs as modulators of MCU channel for clinical therapeutics

•The highly selective mitochondrial Ca2+ uptake channel MCU play a crucial role in cellular Ca2+ homeostasis and bioenergetics. Recently, De Mario et al., conducted small molecule screen to identify MCU modulators that control mitochondrial Ca2+ uptake as a proof-of-concept. [Display omitted]

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Bibliographic Details
Published in:Cell calcium (Edinburgh) 2021-11, Vol.99, p.102456-102456, Article 102456
Main Authors: Vishnu, Neelanjan, Wilson, Justin, Madesh, Muniswamy
Format: Article
Language:English
Subjects:
Calcium Channels - metabolism
Calcium Signaling
Pharmaceutical Preparations
Citations: Items that this one cites
Online Access:Get full text
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Summary:•The highly selective mitochondrial Ca2+ uptake channel MCU play a crucial role in cellular Ca2+ homeostasis and bioenergetics. Recently, De Mario et al., conducted small molecule screen to identify MCU modulators that control mitochondrial Ca2+ uptake as a proof-of-concept. [Display omitted]
ISSN:0143-4160
1532-1991
DOI:10.1016/j.ceca.2021.102456