Survival benefit of a combined surgical approach in patients with metastatic breast cancer

Background We previously reported survival benefit of surgery in patients with stage IV breast cancer (BC); prospective trials yielded inconclusive results. Methods We sampled the National Cancer Database (2004–2016) for de novo stage IV BC patients undergoing both primary site resection and metasta...

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Bibliographic Details
Published in:Journal of surgical oncology 2021-12, Vol.124 (8), p.1235-1241
Main Authors: Bilani, Nadeem, Yaghi, Marita, Singh Jabbal, Iktej, Elson, Leah, Elimimian, Elizabeth Blessing, Liang, Hong, Nahleh, Zeina
Format: Article
Language:English
Subjects:
Breast cancer
breast neoplasms
Lumpectomy
Mastectomy
medical oncology
metastasectomy
Metastasis
registries
Surgery
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Summary:Background We previously reported survival benefit of surgery in patients with stage IV breast cancer (BC); prospective trials yielded inconclusive results. Methods We sampled the National Cancer Database (2004–2016) for de novo stage IV BC patients undergoing both primary site resection and metastasectomy. A multivariate Cox‐regression survival model investigated the overall survival (OS) of this surgical approach as compared to lumpectomy/mastectomy alone, metastasectomy alone, or no surgery. The Kaplan–Meier method was used to demonstrate the utility of surgery when metastasis were confined to 1 site stratifying by tissue type. Results A total of n = 55,125 patients were included. As compared to lumpectomy/mastectomy alone (43 months), lumpectomy/mastectomy + metastasectomy exhibited the best OS (50 months, p = 0.012), metastasectomy alone showed slightly worse OS (30 months, p 
ISSN:0022-4790
1096-9098
DOI:10.1002/jso.26656