Bioinspired Conjugated Tri-Porphyrin-Based Intracellular pH-Sensitive Metallo-Supramolecular Nanoparticles for Near-Infrared Photoacoustic Imaging-Guided Chemo- and Photothermal Combined Therapy

Porphyrins have been extensively used in clinical phototherapy. However, most of them exhibited absorption below 700 nm. We report conjugated tri-porphyrins showing absorption within a biological phototherapy window (700–850 nm). On this basis, bioinspired intracellular pH-sensitive metallo-supramol...

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Bibliographic Details
Published in:ACS biomaterials science & engineering 2021-09, Vol.7 (9), p.4503-4508
Main Authors: Zhang, Zhe, Tang, Weiwei, Li, Yufeng, Cao, Yue, Shang, Yuanhong
Format: Article
Language:English
Subjects:
Controlled Release and Delivery Systems
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Summary:Porphyrins have been extensively used in clinical phototherapy. However, most of them exhibited absorption below 700 nm. We report conjugated tri-porphyrins showing absorption within a biological phototherapy window (700–850 nm). On this basis, bioinspired intracellular pH-sensitive metallo-supramolecular nanoparticles (NPs) are designed. They provide the simultaneous photothermal therapy and chemotherapy. After treatment by tail vein injection, the tumor was completely relieved without recurrence in a course of 27 days. These bioinspired intracellular pH-sensitive metallo-supramolecular NPs show excellent potential application in near-infrared photoacoustic imaging-guided chemo-photothermal combined therapy.
ISSN:2373-9878
2373-9878
DOI:10.1021/acsbiomaterials.1c00597