Recent advances in emerging three-dimensional in vitro models for sport-related traumatic brain injury

Sports-related traumatic brain injury (srTBI) is a traumatic brain injury (TBI) caused by sports, which can result in cognitive and motor dysfunction. Currently, research on the molecular mechanism of srTBI and related drug development mainly relies on monolayer culture models and animal models. How...

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Bibliographic Details
Published in:Sheng wu yi xue gong cheng xue za zhi 2021-08, Vol.38 (4), p.797-804
Main Authors: Du, Xincheng, Wang, Jibo, Zhao, Wen, Chen, Pu, Ou, Gaozhi
Format: Article
Language:Chinese
Subjects:
Animals
Brain Injuries
Brain Injuries, Traumatic
Humans
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Summary:Sports-related traumatic brain injury (srTBI) is a traumatic brain injury (TBI) caused by sports, which can result in cognitive and motor dysfunction. Currently, research on the molecular mechanism of srTBI and related drug development mainly relies on monolayer culture models and animal models. However, many differences exist in cell populations and inflammatory responses between these models and human pathophysiological processes. Most of the researches derived from the models can't effectively conducted translational research. Emerging three-dimensional (3D) models bridge the limitations of traditional models in simulating the pathophysiological processes of human srTBI and provide new means to understand srTBI. A literature has reported the research progress of emerging 3D models in neurological diseases, but there is a lack of systematic summary of the mentioned models in srTBI studies. Here, we review the research progress of emerging 3D models of srTBI, discuss the advantages and limitations of existin
ISSN:1001-5515
DOI:10.7507/1001-5515.202012050