Synthesis of Murrayaquinone‐A Derivatives and Investigation of Potential Anticancer Properties

A series of novel murrayaquinone a derivatives were synthesized and their anti‐cancer activity were evaluated on healthy colon cell lines (CCD‐18Co), primary (Caco‐2) and metastatic (DLD‐1) colon cancer cell lines. The results showed that the cytotoxicity of murrayaquinone molecules is significantly...

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Bibliographic Details
Published in:Chemistry & biodiversity 2021-11, Vol.18 (11), p.e2100348-n/a
Main Authors: Cagatay, Elcin, Akyildiz, Volkan, Ergun, Yavuz, Kayali, Hulya Ayar
Format: Article
Language:English
Subjects:
Alkaloids - chemical synthesis
Alkaloids - chemistry
Alkaloids - pharmacology
anti-tumor activity
Anticancer properties
Antineoplastic Agents - chemical synthesis
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Apoptosis
Benzoquinones - chemical synthesis
Benzoquinones - chemistry
Benzoquinones - pharmacology
Cancer
Carbazoles - chemical synthesis
Carbazoles - chemistry
Carbazoles - pharmacology
Cell cycle
Cell Cycle Checkpoints - drug effects
Cell Line
Cell Proliferation - drug effects
Cell Survival - drug effects
Colon
Colon cancer
colon cancer cell lines
Colorectal cancer
Cytotoxicity
Drug Screening Assays, Antitumor
Humans
Metastases
Molecular Structure
murrayaquinone A
organic synthesis
Toxicity
Tumor cell lines
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Summary:A series of novel murrayaquinone a derivatives were synthesized and their anti‐cancer activity were evaluated on healthy colon cell lines (CCD‐18Co), primary (Caco‐2) and metastatic (DLD‐1) colon cancer cell lines. The results showed that the cytotoxicity of murrayaquinone molecules is significantly high even in micromolar levels. The DNA binding, cell cycle arrest and metabolic activity studies of these molecules were also carried out and the results showed that these molecules induce apoptosis. In conclusion, the data support further studies on murrayaquinone derivatives toward selection of a candidate for cancer treatment.
ISSN:1612-1872
1612-1880
DOI:10.1002/cbdv.202100348