Synthesis of Murrayaquinone‐A Derivatives and Investigation of Potential Anticancer Properties

• Published in: Chemistry & biodiversity 2021-11, Vol.18 (11), p.e2100348-n/a
• Main Authors: Cagatay, Elcin, Akyildiz, Volkan, Ergun, Yavuz, Kayali, Hulya Ayar
• Format: Article
• Language: English
• Subjects: Alkaloids - chemical synthesis; Alkaloids - chemistry; Alkaloids - pharmacology; anti-tumor activity; Anticancer properties; Antineoplastic Agents - chemical synthesis; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Apoptosis; Benzoquinones - chemical synthesis; Benzoquinones - chemistry; Benzoquinones - pharmacology; Cancer; Carbazoles - chemical synthesis; Carbazoles - chemistry; Carbazoles - pharmacology; Cell cycle; Cell Cycle Checkpoints - drug effects; Cell Line; Cell Proliferation - drug effects; Cell Survival - drug effects; Colon; Colon cancer; colon cancer cell lines; Colorectal cancer; Cytotoxicity; Drug Screening Assays, Antitumor; Humans; Metastases; Molecular Structure; murrayaquinone A; organic synthesis; Toxicity; Tumor cell lines
• ISSN: 1612-1872; 1612-1880
• DOI: 10.1002/cbdv.202100348

A series of novel murrayaquinone a derivatives were synthesized and their anti‐cancer activity were evaluated on healthy colon cell lines (CCD‐18Co), primary (Caco‐2) and metastatic (DLD‐1) colon cancer cell lines. The results showed that the cytotoxicity of murrayaquinone molecules is significantly high even in micromolar levels. The DNA binding, cell cycle arrest and metabolic activity studies of these molecules were also carried out and the results showed that these molecules induce apoptosis. In conclusion, the data support further studies on murrayaquinone derivatives toward selection of a candidate for cancer treatment.