Effect of Dietary Lactobacillus casei on Physiometabolic Responses and Liver Histopathology in Common Carp (Cyprinus carpio) After Exposure to Iron Oxide Nanoparticles

A 60-day feeding trial was performed to assess the dietary effect of Lactobacillus casei as a probiotic supplement on some serum biochemical parameters and liver histopathology in common carp fry after exposure to iron oxide nanoparticles (IoNPs). Six treatments were prepared as follows: control (no...

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Bibliographic Details
Published in:Biological trace element research 2022-07, Vol.200 (7), p.3346-3354
Main Authors: Hedayati, Seyed Aliakbar, Sheikh Veisi, Rouhollah, Hosseini Shekarabi, Seyed Pezhman, Shahbazi Naserabad, Saeid, Bagheri, Dara, Ghafarifarsani, Hamed
Format: Article
Language:English
Subjects:
Alanine
Alanine transaminase
Antioxidants
Aspartate aminotransferase
Atrophy
Biochemistry
Biomedical and Life Sciences
Biotechnology
Carp
Cyprinus carpio
Diet
Exposure
Feeding experiments
Fish
Freshwater fishes
Glutathione
Glutathione transferase
Hepatocytes
Histopathology
Hormones
Hyperemia
Iron oxides
Lactobacilli
Lactobacillus casei
Life Sciences
Liver
Nanoparticles
Necrosis
Nutrition
Oncology
Probiotics
Serum
Transaminases
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Summary:A 60-day feeding trial was performed to assess the dietary effect of Lactobacillus casei as a probiotic supplement on some serum biochemical parameters and liver histopathology in common carp fry after exposure to iron oxide nanoparticles (IoNPs). Six treatments were prepared as follows: control (no IoNP exposure and no dietary probiotic), P6: 10 6  CFU/g probiotic diet, P7: 10 7  CFU/g probiotic diet, NPs: 0.15 mg/l IoNPs, NPs + P6: 0.15 mg/l IoNPs with 10 6  CFU/g probiotic diet, and NPs + P7: 0.15 mg/l IoNPs with 10 7  CFU/gprobiotic diet. Based on the results, serum aspartate aminotransferase and alanine aminotransferase levels were significantly increased in 0.15 mg/l IoNPs, P7, and NPs + P6 treatments compared to the control group. In addition, the examination of antioxidant enzymes showed a significant increase in the levels of cortisol and glutathione S-transferase as well as malondialdehyde level. IoNPs also caused significant histopathological changes in the fish liver during the experiment such as hyperemia in sinusoidal spaces, hepatocytes vacuolation and necrosis, pyknosis, and disruption of hepatic lobules and atrophy. Results revealed the protective effects of dietary L. casei to mitigate the adverse impacts of IoNPs on the physiological processes of common carp.
ISSN:0163-4984
1559-0720
DOI:10.1007/s12011-021-02906-9