Prognostic Impact of Echocardiographic Diastolic Dysfunction on Outcomes in Patients With Heart Failure With Preserved Ejection Fraction　― Insights From the PURSUIT-HFpEF Registry

Background:Although diastolic dysfunction is important pathophysiology in heart failure with preserved ejection fraction (HFpEF), its prognostic impact in HFpEF patients, including those with atrial fibrillation (AF), remains to be elucidated.Methods and Results:We included the data for 863 patients...

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Published in:Circulation Journal 2021/12/24, Vol.86(1), pp.23-33
Main Authors: Oeun, Bolrathanak, Hikoso, Shungo, Nakatani, Daisaku, Mizuno, Hiroya, Suna, Shinichiro, Kitamura, Tetsuhisa, Okada, Katsuki, Dohi, Tomoharu, Sotomi, Yohei, Kojima, Takayuki, Kida, Hirota, Sunaga, Akihiro, Sato, Taiki, Takeda, Yasuharu, Kurakami, Hiroyuki, Yamada, Tomomi, Tamaki, Shunsuke, Abe, Haruhiko, Nakagawa, Yusuke, Higuchi, Yoshiharu, Fuji, Hisakazu, Mano, Toshiaki, Uematsu, Masaaki, Yasumura, Yoshio, Yamada, Takahisa, Sakata, Yasushi, on behalf of the OCVC-Heart Failure Investigators
Format: Article
Language:English
Subjects:
Aged, 80 and over
Atrial fibrillation
Atrial Fibrillation - diagnostic imaging
Diastolic dysfunction
Echocardiography - methods
Female
Heart Failure - diagnostic imaging
Heart failure with preserved ejection fraction (HFpEF)
Humans
Prognosis
Prospective Studies
Registries
Stroke Volume - physiology
Ventricular Function, Left - physiology
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Summary:Background:Although diastolic dysfunction is important pathophysiology in heart failure with preserved ejection fraction (HFpEF), its prognostic impact in HFpEF patients, including those with atrial fibrillation (AF), remains to be elucidated.Methods and Results:We included the data for 863 patients (321 patients with AF) registered in a prospective multicenter observational study of patients with HFpEF. Patients were divided into 3 groups according to the 2016 ASE/EACVI recommendations. The primary endpoint was a composite of all-cause death or HF rehospitalization. Median age was 83 years, and 55.5% were female. 196 (22.7%) were classified with normal diastolic function (ND), 253 (29.3%) with indeterminate (ID) and 414 (48.0%) with diastolic dysfunction (DD). The primary endpoint occurred more frequently in patients with DD than in those with ND or ID (log-rank P
ISSN:1346-9843
1347-4820
1347-4820
DOI:10.1253/circj.CJ-21-0300