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Endocrine disruptors: Challenges and future directions in epidemiologic research
Public concern about the impact of endocrine disrupting chemicals (EDCs) on both humans and the environment is growing steadily. Epidemiologic research provides key information towards our understanding of the relationship between environmental exposures like EDCs and human health outcomes. Intended...
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Published in: | Environmental research 2022-03, Vol.204 (Pt A), p.111969-111969, Article 111969 |
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creator | Ho, V. Pelland-St-Pierre, L. Gravel, S. Bouchard, M.F. Verner, M.-A. Labrèche, F. |
description | Public concern about the impact of endocrine disrupting chemicals (EDCs) on both humans and the environment is growing steadily. Epidemiologic research provides key information towards our understanding of the relationship between environmental exposures like EDCs and human health outcomes. Intended for researchers in disciplines complementary to epidemiology, this paper highlights the importance and challenges of epidemiologic research in order to present the key elements pertaining to the design and interpretation of an epidemiologic study on EDCs.
The conduct of observational studies on EDCs derives from a thoughtful research question, which will help determine the subsequent methodological choices surrounding the careful selection of the study population (including the comparison group), the adequate ascertainment of exposure(s) and outcome(s) of interest, and the application of methodological and statistical concepts more specific to epidemiology. The interpretation of epidemiologic results may be arduous due to the latency occurring between EDC exposure and certain outcome(s), the complexity in capturing EDC exposure(s), and traditional methodological and statistical issues that also deserve consideration (e.g., confounding, effect modification, non-monotonic responses). Moving forward, we strongly advocate for an integrative approach of expertise in the fields of epidemiology, exposure science, risk assessment and toxicology to adequately study the health risks associated with EDCs while tackling their challenges.
•Evidence on adverse effects of endocrine disrupting chemicals (EDCs) is accumulating.•Human studies obviate the need for inter-species extrapolations, but are arduous.•We present key elements of epidemiologic studies on EDCs, for non-epidemiologists.•Epidemiologic research can study realistic exposure routes, mixtures and durations.•Let's integrate epidemiology, exposure science, risk assessment and toxicology!. |
doi_str_mv | 10.1016/j.envres.2021.111969 |
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The conduct of observational studies on EDCs derives from a thoughtful research question, which will help determine the subsequent methodological choices surrounding the careful selection of the study population (including the comparison group), the adequate ascertainment of exposure(s) and outcome(s) of interest, and the application of methodological and statistical concepts more specific to epidemiology. The interpretation of epidemiologic results may be arduous due to the latency occurring between EDC exposure and certain outcome(s), the complexity in capturing EDC exposure(s), and traditional methodological and statistical issues that also deserve consideration (e.g., confounding, effect modification, non-monotonic responses). Moving forward, we strongly advocate for an integrative approach of expertise in the fields of epidemiology, exposure science, risk assessment and toxicology to adequately study the health risks associated with EDCs while tackling their challenges.
•Evidence on adverse effects of endocrine disrupting chemicals (EDCs) is accumulating.•Human studies obviate the need for inter-species extrapolations, but are arduous.•We present key elements of epidemiologic studies on EDCs, for non-epidemiologists.•Epidemiologic research can study realistic exposure routes, mixtures and durations.•Let's integrate epidemiology, exposure science, risk assessment and toxicology!.</description><identifier>ISSN: 0013-9351</identifier><identifier>EISSN: 1096-0953</identifier><identifier>DOI: 10.1016/j.envres.2021.111969</identifier><identifier>PMID: 34461123</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Endocrine disrupting chemicals ; Endocrine Disruptors - toxicity ; Environmental Exposure ; Environmental Pollutants - toxicity ; Epidemiologic Studies ; Epidemiology ; Human studies ; Humans ; Risk Assessment</subject><ispartof>Environmental research, 2022-03, Vol.204 (Pt A), p.111969-111969, Article 111969</ispartof><rights>2021 The Authors</rights><rights>Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c408t-ea2aa7a6a39904d3cea2ea0646ffdcf6a9fdc310acd3d944b802b9bb073b61e43</citedby><cites>FETCH-LOGICAL-c408t-ea2aa7a6a39904d3cea2ea0646ffdcf6a9fdc310acd3d944b802b9bb073b61e43</cites><orcidid>0000-0002-6773-7993 ; 0000-0002-0724-7917 ; 0000-0001-8722-0433 ; 0000-0002-1935-8913</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34461123$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ho, V.</creatorcontrib><creatorcontrib>Pelland-St-Pierre, L.</creatorcontrib><creatorcontrib>Gravel, S.</creatorcontrib><creatorcontrib>Bouchard, M.F.</creatorcontrib><creatorcontrib>Verner, M.-A.</creatorcontrib><creatorcontrib>Labrèche, F.</creatorcontrib><title>Endocrine disruptors: Challenges and future directions in epidemiologic research</title><title>Environmental research</title><addtitle>Environ Res</addtitle><description>Public concern about the impact of endocrine disrupting chemicals (EDCs) on both humans and the environment is growing steadily. Epidemiologic research provides key information towards our understanding of the relationship between environmental exposures like EDCs and human health outcomes. Intended for researchers in disciplines complementary to epidemiology, this paper highlights the importance and challenges of epidemiologic research in order to present the key elements pertaining to the design and interpretation of an epidemiologic study on EDCs.
The conduct of observational studies on EDCs derives from a thoughtful research question, which will help determine the subsequent methodological choices surrounding the careful selection of the study population (including the comparison group), the adequate ascertainment of exposure(s) and outcome(s) of interest, and the application of methodological and statistical concepts more specific to epidemiology. The interpretation of epidemiologic results may be arduous due to the latency occurring between EDC exposure and certain outcome(s), the complexity in capturing EDC exposure(s), and traditional methodological and statistical issues that also deserve consideration (e.g., confounding, effect modification, non-monotonic responses). Moving forward, we strongly advocate for an integrative approach of expertise in the fields of epidemiology, exposure science, risk assessment and toxicology to adequately study the health risks associated with EDCs while tackling their challenges.
•Evidence on adverse effects of endocrine disrupting chemicals (EDCs) is accumulating.•Human studies obviate the need for inter-species extrapolations, but are arduous.•We present key elements of epidemiologic studies on EDCs, for non-epidemiologists.•Epidemiologic research can study realistic exposure routes, mixtures and durations.•Let's integrate epidemiology, exposure science, risk assessment and toxicology!.</description><subject>Endocrine disrupting chemicals</subject><subject>Endocrine Disruptors - toxicity</subject><subject>Environmental Exposure</subject><subject>Environmental Pollutants - toxicity</subject><subject>Epidemiologic Studies</subject><subject>Epidemiology</subject><subject>Human studies</subject><subject>Humans</subject><subject>Risk Assessment</subject><issn>0013-9351</issn><issn>1096-0953</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9kEtLAzEQgIMoWqv_QGSPXrZONtm08SBIqQ8o6EHPIZvMtinbpCa7Bf-9W1Y9ehpm-Ob1EXJFYUKBitvNBP0-YpoUUNAJpVQKeURGFKTIQZbsmIwAKMslK-kZOU9p06e0ZHBKzhjngtKCjcjbwttgovOYWZdit2tDTHfZfK2bBv0KU6a9zequ7eKBiGhaF3zKnM9w5yxuXWjCypmsvwR1NOsLclLrJuHlTxyTj8fF-_w5X74-vcwflrnhMGtz1IXWUy00kxK4ZaYvoAbBRV1bUwst-8AoaGOZlZxXMygqWVUwZZWgyNmY3AxzdzF8dphatXXJYNNoj6FLqijFVM6ghKJH-YCaGFKKWKtddFsdvxQFdXCpNmpwqQ4u1eCyb7v-2dBVW7R_Tb_yeuB-ALD_c-8wqmQceoODJ2WD-3_DN0o0iPc</recordid><startdate>202203</startdate><enddate>202203</enddate><creator>Ho, V.</creator><creator>Pelland-St-Pierre, L.</creator><creator>Gravel, S.</creator><creator>Bouchard, M.F.</creator><creator>Verner, M.-A.</creator><creator>Labrèche, F.</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6773-7993</orcidid><orcidid>https://orcid.org/0000-0002-0724-7917</orcidid><orcidid>https://orcid.org/0000-0001-8722-0433</orcidid><orcidid>https://orcid.org/0000-0002-1935-8913</orcidid></search><sort><creationdate>202203</creationdate><title>Endocrine disruptors: Challenges and future directions in epidemiologic research</title><author>Ho, V. ; Pelland-St-Pierre, L. ; Gravel, S. ; Bouchard, M.F. ; Verner, M.-A. ; Labrèche, F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c408t-ea2aa7a6a39904d3cea2ea0646ffdcf6a9fdc310acd3d944b802b9bb073b61e43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Endocrine disrupting chemicals</topic><topic>Endocrine Disruptors - toxicity</topic><topic>Environmental Exposure</topic><topic>Environmental Pollutants - toxicity</topic><topic>Epidemiologic Studies</topic><topic>Epidemiology</topic><topic>Human studies</topic><topic>Humans</topic><topic>Risk Assessment</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ho, V.</creatorcontrib><creatorcontrib>Pelland-St-Pierre, L.</creatorcontrib><creatorcontrib>Gravel, S.</creatorcontrib><creatorcontrib>Bouchard, M.F.</creatorcontrib><creatorcontrib>Verner, M.-A.</creatorcontrib><creatorcontrib>Labrèche, F.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Environmental research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ho, V.</au><au>Pelland-St-Pierre, L.</au><au>Gravel, S.</au><au>Bouchard, M.F.</au><au>Verner, M.-A.</au><au>Labrèche, F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Endocrine disruptors: Challenges and future directions in epidemiologic research</atitle><jtitle>Environmental research</jtitle><addtitle>Environ Res</addtitle><date>2022-03</date><risdate>2022</risdate><volume>204</volume><issue>Pt A</issue><spage>111969</spage><epage>111969</epage><pages>111969-111969</pages><artnum>111969</artnum><issn>0013-9351</issn><eissn>1096-0953</eissn><abstract>Public concern about the impact of endocrine disrupting chemicals (EDCs) on both humans and the environment is growing steadily. Epidemiologic research provides key information towards our understanding of the relationship between environmental exposures like EDCs and human health outcomes. Intended for researchers in disciplines complementary to epidemiology, this paper highlights the importance and challenges of epidemiologic research in order to present the key elements pertaining to the design and interpretation of an epidemiologic study on EDCs.
The conduct of observational studies on EDCs derives from a thoughtful research question, which will help determine the subsequent methodological choices surrounding the careful selection of the study population (including the comparison group), the adequate ascertainment of exposure(s) and outcome(s) of interest, and the application of methodological and statistical concepts more specific to epidemiology. The interpretation of epidemiologic results may be arduous due to the latency occurring between EDC exposure and certain outcome(s), the complexity in capturing EDC exposure(s), and traditional methodological and statistical issues that also deserve consideration (e.g., confounding, effect modification, non-monotonic responses). Moving forward, we strongly advocate for an integrative approach of expertise in the fields of epidemiology, exposure science, risk assessment and toxicology to adequately study the health risks associated with EDCs while tackling their challenges.
•Evidence on adverse effects of endocrine disrupting chemicals (EDCs) is accumulating.•Human studies obviate the need for inter-species extrapolations, but are arduous.•We present key elements of epidemiologic studies on EDCs, for non-epidemiologists.•Epidemiologic research can study realistic exposure routes, mixtures and durations.•Let's integrate epidemiology, exposure science, risk assessment and toxicology!.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>34461123</pmid><doi>10.1016/j.envres.2021.111969</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-6773-7993</orcidid><orcidid>https://orcid.org/0000-0002-0724-7917</orcidid><orcidid>https://orcid.org/0000-0001-8722-0433</orcidid><orcidid>https://orcid.org/0000-0002-1935-8913</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Endocrine disrupting chemicals Endocrine Disruptors - toxicity Environmental Exposure Environmental Pollutants - toxicity Epidemiologic Studies Epidemiology Human studies Humans Risk Assessment |
title | Endocrine disruptors: Challenges and future directions in epidemiologic research |
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