Surface Modification of Alginate Microcarriers for Improvement of Their Biological Properties

The obtaining of microcarriers for the cell culture and delivery is an urgent task of tissue engineering and regenerative medicine. The novel method of surface modification of alginate microcarriers in the form of microspheres with a diameter of 200–300 μm was developed. The described method consist...

Full description

Saved in:
Bibliographic Details
Published in:Doklady. Biological sciences 2021-07, Vol.499 (1), p.97-98
Main Authors: Safonova, L. A., Bobrova, M. M., Efimov, A. E., Agapova, O. I., Agapov, I. I., Gautier, S. V.
Format: Article
Language:English
Subjects:
Alginates
Alginic acid
Biomedical and Life Sciences
Cell culture
Collagen
Evolutionary Biology
Life Sciences
Microspheres
Plant Sciences
Regenerative medicine
Tissue engineering
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The obtaining of microcarriers for the cell culture and delivery is an urgent task of tissue engineering and regenerative medicine. The novel method of surface modification of alginate microcarriers in the form of microspheres with a diameter of 200–300 μm was developed. The described method consists in covalent crosslinking between collagen and surface of alginate microcarriers. It was shown that the method makes it possible to completely modify the surface of the alginate microcarrier, which can be used to improve the biological properties of the microcarrier. Such microcarriers with improved biological properties can be considered as effective systems for cell delivery and culture.
ISSN:0012-4966
1608-3105
DOI:10.1134/S0012496621040050