Revisiting the bipolar disorder with migraine phenotype: Clinical features and comorbidity

•Almost one third (29%) of patients with BD have experienced migraine headaches.•Migraine is associated with evening chronotype and anxiety disorders.•A younger age and female sex are associated with migraine.•Migraine is associated with fibromyalgia, psoriasis, and asthma.•Migraine was not associat...

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Bibliographic Details
Published in:Journal of affective disorders 2021-12, Vol.295, p.156-162
Main Authors: Romo-Nava, Francisco, Blom, Thomas, Cuellar-Barboza, Alfredo B., Awosika, Oluwole O., Martens, Brian E., Mori, Nicole N., Colby, Colin L., Prieto, Miguel L., Veldic, Marin, Singh, Balwinder, Gardea-Resendez, Manuel, Nunez, Nicolas A., Ozerdem, Aysegul, Biernacka, Joanna M., Frye, Mark A., McElroy, Susan L.
Format: Article
Language:English
Subjects:
Bipolar Disorder - epidemiology
Comorbidity
Cross-Sectional Studies
Female
Humans
Male
Migraine Disorders - epidemiology
Phenotype
Prevalence
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Summary:•Almost one third (29%) of patients with BD have experienced migraine headaches.•Migraine is associated with evening chronotype and anxiety disorders.•A younger age and female sex are associated with migraine.•Migraine is associated with fibromyalgia, psoriasis, and asthma.•Migraine was not associated with BD subtype, onset, eating behavior, or suicidality. To evaluate the prevalence and clinical correlates of lifetime migraine among patients with bipolar disorder (BD). In a cross-sectional study, we evaluated 721 adults with BD from the Mayo Clinic Bipolar Disorder Biobank and compared clinical correlates of those with and without a lifetime history of migraine. A structured clinical interview (DSM-IV) and a clinician-assessed questionnaire were utilized to establish a BD diagnosis, lifetime history of migraine, and clinical correlates. Two hundred and seven (29%) BD patients had a lifetime history of migraine. BD patients with migraine were younger and more likely to be female as compared to those without migraine (p values
ISSN:0165-0327
1573-2517
DOI:10.1016/j.jad.2021.08.026