Improvement of electroacupuncture on APP/PS1 transgenic mice in behavioral probably due to reducing deposition of Aβ in hippocampus

• Published in: Anatomical record (Hoboken, N.J. : 2007) N.J. : 2007), 2021-11, Vol.304 (11), p.2521-2530
• Main Authors: Sun, Run‐Quan, Wang, Zi‐Dong, Zhao, Jun, Wang, Shuai, Liu, Yi‐Zhi, Liu, Si‐Yuan, Li, Zhi‐Gang, Wang, Xin
• Format: Article
• Language: English
• Subjects: [18F]AV‐45; Acupuncture; Alzheimer's disease; Amyloid; Animal models; Aβ deposition; Aβ沉积; cognition; Cognitive ability; Electroacupuncture; Hippocampus; Memory; Neurodegenerative diseases; Neurological diseases; Positron emission tomography; Presenilin 1; Spatial discrimination learning; Spatial memory; Transgenic mice; 电针; 认知; 阿尔茨海默病
• ISSN: 1932-8486; 1932-8494
• DOI: 10.1002/ar.24737

Alzheimer's disease (AD) is a fatal neurodegenerative disease for which currently no cure is available. Electroacupuncture (EA) has been widely used in China as an alternative therapeutic approach for neurological diseases. The cognitive decline in patients with AD has been reported to be closely related to the deposition of amyloid‐β (Aβ) in the hippocampus of the brain, and the Morris water maze (MWM) test is a widely used method for assessing the behavior of animal models. In this study, the MWM test was performed to evaluate the effects of EA treatment on cognitive function and memory, and the micro‐positron emission tomography scan was used to assess the hippocampal Aβ deposition. The results showed that the cognitive function of APP/PS1 mice was significantly improved and the rate of [18F]AV‐45 uptake was reduced in the EA group, compared with the AD group. Our study suggested that EA can exert a therapeutic effect in AD by improving spatial learning and memory and inhibiting the hippocampal Aβ deposition. 电针对APP/PS1转基因小鼠行为学的改善可能与减少海马Aβ沉积有关 摘要:老年痴呆症疾病(AD)是一种致命的神经退行性疾病，目前没有治愈方法。电针作为神经疾病的替代治疗手段，在我国已得到广泛应用。据报道，阿尔茨海默病患者的认知功能下降与β‐淀粉样蛋白沉积于大脑海马区关系密切，Morris水迷宫(MWM)试验是一种广泛应用的动物模型行为评估方法，本研究采用Morris水迷宫试验评估电针治疗对阿尔茨海默病模型动物认知功能和记忆的影响，并用微型正电子断层扫面技术评估海马区β‐淀粉样蛋白沉积，结果表明电针组与模型组相比，APP/PS1小鼠认知功能明显改善，[18F]AV‐45摄取率降低，我们的研究提示电针可通过改善模型动物小鼠空间学习记忆和抑制海马区β‐淀粉样蛋白沉积，对阿尔茨海默病起到一定的治疗作用。.