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circPTPN22 attenuates immune microenvironment of pancreatic cancer via STAT3 acetylation
Accumulating research implicated that circular RNAs exhibited significant roles in cancer development. Nonetheless, the role regarding circPTPN22 in pancreatic cancer remains unclear. Expression of circPTPN22 in pancreatic cancer cell lines and normal cells was determined with quantitative real-time...
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| Published in: | Cancer gene therapy 2023-04, Vol.30 (4), p.559-566 |
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| container_end_page | 566 |
| container_issue | 4 |
| container_start_page | 559 |
| container_title | Cancer gene therapy |
| container_volume | 30 |
| creator | He, Yuan Han, Pengyong Chen, Chuang Xie, Shuzhe Zhang, Huiqing Song, Yingming Hu, Hao Zhao, Qiang Lian, Changhong |
| description | Accumulating research implicated that circular RNAs exhibited significant roles in cancer development. Nonetheless, the role regarding circPTPN22 in pancreatic cancer remains unclear. Expression of circPTPN22 in pancreatic cancer cell lines and normal cells was determined with quantitative real-time PCR (qRT-PCR). Cell counting kit-8 assay and colony formation assay were used to measure the proliferation of pancreatic cancer cells. RNA immunoprecipitation and Western blot were employed for investigation the binding between circPTPN22 and STAT3. circPTPN22 expression was highly upregulated in pancreatic cancer tissues and cell lines. Knockdown of circPTPN22 inhibited cell proliferation and attenuates pancreatic cancer immune microenvironment. Furthermore, STAT3 acetylation was involved in these effects. circPTPN22 promoted STAT3 acetylation via inhibiting STAT3/SIRT1 interaction. circPTPN22 attenuates pancreatic cancer immune microenvironment by promoting STAT3 acetylation via inhibiting STAT3/SIRT1 interaction. |
| doi_str_mv | 10.1038/s41417-021-00382-w |
| format | article |
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Nonetheless, the role regarding circPTPN22 in pancreatic cancer remains unclear. Expression of circPTPN22 in pancreatic cancer cell lines and normal cells was determined with quantitative real-time PCR (qRT-PCR). Cell counting kit-8 assay and colony formation assay were used to measure the proliferation of pancreatic cancer cells. RNA immunoprecipitation and Western blot were employed for investigation the binding between circPTPN22 and STAT3. circPTPN22 expression was highly upregulated in pancreatic cancer tissues and cell lines. Knockdown of circPTPN22 inhibited cell proliferation and attenuates pancreatic cancer immune microenvironment. Furthermore, STAT3 acetylation was involved in these effects. circPTPN22 promoted STAT3 acetylation via inhibiting STAT3/SIRT1 interaction. circPTPN22 attenuates pancreatic cancer immune microenvironment by promoting STAT3 acetylation via inhibiting STAT3/SIRT1 interaction.</description><identifier>ISSN: 0929-1903</identifier><identifier>EISSN: 1476-5500</identifier><identifier>DOI: 10.1038/s41417-021-00382-w</identifier><identifier>PMID: 34471233</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>13 ; 631/67/327 ; 631/80 ; Acetylation ; Antibodies ; Apoptosis ; Biomedical and Life Sciences ; Biomedicine ; Cancer therapies ; Cell Line, Tumor ; Cell proliferation ; Cell Proliferation - genetics ; Cells ; Chemotherapy ; Flow cytometry ; Gene Expression ; Gene Therapy ; Humans ; Immunoprecipitation ; Immunotherapy ; Medical prognosis ; Metastasis ; Microenvironments ; Pancreatic cancer ; Pancreatic Neoplasms ; Pancreatic Neoplasms - genetics ; Pancreatic Neoplasms - metabolism ; Proteins ; Radiation therapy ; RNA ; SIRT1 protein ; Sirtuin 1 - genetics ; Sirtuin 1 - metabolism ; Stat3 protein ; STAT3 Transcription Factor - genetics ; STAT3 Transcription Factor - metabolism ; Surgery ; Tumor cell lines ; Tumor Microenvironment - genetics</subject><ispartof>Cancer gene therapy, 2023-04, Vol.30 (4), p.559-566</ispartof><rights>The Author(s), under exclusive licence to Springer Nature America, Inc. 2021</rights><rights>2021. The Author(s), under exclusive licence to Springer Nature America, Inc.</rights><rights>The Author(s), under exclusive licence to Springer Nature America, Inc. 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-p213t-2f0f13ad6f52dddb0adbb0ae92429f5c02f88093d87d7dcdedd76cc9be6b068e3</cites><orcidid>0000-0002-3018-7983 ; 0000-0003-3215-8673</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34471233$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>He, Yuan</creatorcontrib><creatorcontrib>Han, Pengyong</creatorcontrib><creatorcontrib>Chen, Chuang</creatorcontrib><creatorcontrib>Xie, Shuzhe</creatorcontrib><creatorcontrib>Zhang, Huiqing</creatorcontrib><creatorcontrib>Song, Yingming</creatorcontrib><creatorcontrib>Hu, Hao</creatorcontrib><creatorcontrib>Zhao, Qiang</creatorcontrib><creatorcontrib>Lian, Changhong</creatorcontrib><title>circPTPN22 attenuates immune microenvironment of pancreatic cancer via STAT3 acetylation</title><title>Cancer gene therapy</title><addtitle>Cancer Gene Ther</addtitle><addtitle>Cancer Gene Ther</addtitle><description>Accumulating research implicated that circular RNAs exhibited significant roles in cancer development. Nonetheless, the role regarding circPTPN22 in pancreatic cancer remains unclear. Expression of circPTPN22 in pancreatic cancer cell lines and normal cells was determined with quantitative real-time PCR (qRT-PCR). Cell counting kit-8 assay and colony formation assay were used to measure the proliferation of pancreatic cancer cells. RNA immunoprecipitation and Western blot were employed for investigation the binding between circPTPN22 and STAT3. circPTPN22 expression was highly upregulated in pancreatic cancer tissues and cell lines. Knockdown of circPTPN22 inhibited cell proliferation and attenuates pancreatic cancer immune microenvironment. Furthermore, STAT3 acetylation was involved in these effects. circPTPN22 promoted STAT3 acetylation via inhibiting STAT3/SIRT1 interaction. circPTPN22 attenuates pancreatic cancer immune microenvironment by promoting STAT3 acetylation via inhibiting STAT3/SIRT1 interaction.</description><subject>13</subject><subject>631/67/327</subject><subject>631/80</subject><subject>Acetylation</subject><subject>Antibodies</subject><subject>Apoptosis</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer therapies</subject><subject>Cell Line, Tumor</subject><subject>Cell proliferation</subject><subject>Cell Proliferation - genetics</subject><subject>Cells</subject><subject>Chemotherapy</subject><subject>Flow cytometry</subject><subject>Gene Expression</subject><subject>Gene Therapy</subject><subject>Humans</subject><subject>Immunoprecipitation</subject><subject>Immunotherapy</subject><subject>Medical prognosis</subject><subject>Metastasis</subject><subject>Microenvironments</subject><subject>Pancreatic cancer</subject><subject>Pancreatic Neoplasms</subject><subject>Pancreatic Neoplasms - 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Academic</collection><jtitle>Cancer gene therapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>He, Yuan</au><au>Han, Pengyong</au><au>Chen, Chuang</au><au>Xie, Shuzhe</au><au>Zhang, Huiqing</au><au>Song, Yingming</au><au>Hu, Hao</au><au>Zhao, Qiang</au><au>Lian, Changhong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>circPTPN22 attenuates immune microenvironment of pancreatic cancer via STAT3 acetylation</atitle><jtitle>Cancer gene therapy</jtitle><stitle>Cancer Gene Ther</stitle><addtitle>Cancer Gene Ther</addtitle><date>2023-04-01</date><risdate>2023</risdate><volume>30</volume><issue>4</issue><spage>559</spage><epage>566</epage><pages>559-566</pages><issn>0929-1903</issn><eissn>1476-5500</eissn><abstract>Accumulating research implicated that circular RNAs exhibited significant roles in cancer development. Nonetheless, the role regarding circPTPN22 in pancreatic cancer remains unclear. Expression of circPTPN22 in pancreatic cancer cell lines and normal cells was determined with quantitative real-time PCR (qRT-PCR). Cell counting kit-8 assay and colony formation assay were used to measure the proliferation of pancreatic cancer cells. RNA immunoprecipitation and Western blot were employed for investigation the binding between circPTPN22 and STAT3. circPTPN22 expression was highly upregulated in pancreatic cancer tissues and cell lines. Knockdown of circPTPN22 inhibited cell proliferation and attenuates pancreatic cancer immune microenvironment. Furthermore, STAT3 acetylation was involved in these effects. circPTPN22 promoted STAT3 acetylation via inhibiting STAT3/SIRT1 interaction. circPTPN22 attenuates pancreatic cancer immune microenvironment by promoting STAT3 acetylation via inhibiting STAT3/SIRT1 interaction.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>34471233</pmid><doi>10.1038/s41417-021-00382-w</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-3018-7983</orcidid><orcidid>https://orcid.org/0000-0003-3215-8673</orcidid></addata></record> |
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| subjects | 13 631/67/327 631/80 Acetylation Antibodies Apoptosis Biomedical and Life Sciences Biomedicine Cancer therapies Cell Line, Tumor Cell proliferation Cell Proliferation - genetics Cells Chemotherapy Flow cytometry Gene Expression Gene Therapy Humans Immunoprecipitation Immunotherapy Medical prognosis Metastasis Microenvironments Pancreatic cancer Pancreatic Neoplasms Pancreatic Neoplasms - genetics Pancreatic Neoplasms - metabolism Proteins Radiation therapy RNA SIRT1 protein Sirtuin 1 - genetics Sirtuin 1 - metabolism Stat3 protein STAT3 Transcription Factor - genetics STAT3 Transcription Factor - metabolism Surgery Tumor cell lines Tumor Microenvironment - genetics |
| title | circPTPN22 attenuates immune microenvironment of pancreatic cancer via STAT3 acetylation |
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