Clinical management of amyloid cardiomyopathy

Clinical heart failure, restrictive cardiomyopathy, and arrhythmias are hallmark features of amyloid cardiomyopathy. In contrast to the advancements in targeted therapies, there is a general lack of evidence-based practice guidelines for clinical management of amyloid cardiomyopathy. In this review,...

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Bibliographic Details
Published in:Heart failure reviews 2022-09, Vol.27 (5), p.1549-1557
Main Authors: Kim, Morris M., Kolseth, Clinton M., Carlson, Dayna, Masri, Ahmad
Format: Article
Language:English
Subjects:
Amyloid
Amyloidosis
Beta blockers
Cardiac arrhythmia
Cardiology
Cardiomyopathy
Congestive heart failure
Diuretics
Drug dosages
Enzymes
Heart failure
Hemodynamics
Hospitalization
Hypertension
Hypotension
Medicine
Medicine & Public Health
Orthostatic hypotension
Pulmonary arteries
Stroke
Thromboembolism
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Summary:Clinical heart failure, restrictive cardiomyopathy, and arrhythmias are hallmark features of amyloid cardiomyopathy. In contrast to the advancements in targeted therapies, there is a general lack of evidence-based practice guidelines for clinical management of amyloid cardiomyopathy. In this review, we review the role of routine medical therapy in amyloid cardiomyopathy, from heart failure management to orthostatic hypotension, atrial arrhythmias, thromboembolic complications, and prevention of sudden death. We conclude by discussing approaches to patients with end-stage disease.
ISSN:1382-4147
1573-7322
DOI:10.1007/s10741-021-10159-w