Is local recurrence in bone and soft tissue sarcomas just a local recurrence or does it impact the overall survival, retrospective cohort from a sarcoma referral center

Background and Objectives Sarcoma local recurrence (LR) is often associated with metastasis, but it is unclear if LR can be a causal event leading to metastasis. We question if LR is best viewed as an independent oncologic event or as a worrisome harbinger threatening a patient's overall surviv...

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Bibliographic Details
Published in:Journal of surgical oncology 2021-12, Vol.124 (8), p.1536-1543
Main Authors: Hasan, Obada, Nasir, Momin, Jessar, Muneeba, Hashimi, Mustafa, An, Qiang, Miller, Benjamin J.
Format: Article
Language:English
Subjects:
Bone cancer
extremity
local recurrence
Metastasis
outcome
Sarcoma
survival
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Summary:Background and Objectives Sarcoma local recurrence (LR) is often associated with metastasis, but it is unclear if LR can be a causal event leading to metastasis. We question if LR is best viewed as an independent oncologic event or as a worrisome harbinger threatening a patient's overall survival. Methods We identified patients with LR and/or metastasis from an ongoing cohort of 629 patients with primary sarcoma and performed a detailed review to assess the timing of metastasis resulting in the following groups: (1) Isolated LR, (2) LR before metastasis, (3) LR within 6 months of metastasis, (4) LR 6–12 months after metastasis, (5) LR >12 months after metastasis, and (6) metastasis at diagnosis. Results Overall, 43 patients met the inclusion criteria with an LR rate of 7%. Ten patients (2% of the entire cohort, 23% of LR) developed an LR before or within 6 months of metastasis. For patients without systemic disease preceding LR, 3 of 23 soft tissue sarcoma STS (13%) and 7 of 10 bone sarcoma (70%) subsequently developed metastasis (p 
ISSN:0022-4790
1096-9098
DOI:10.1002/jso.26663