Inflammatory markers in chronic kidney disease and end stage renal disease patients

Background Chronic kidney disease (CKD) is condition characterized by a gradual loss of kidney function, patient with CKD suffering from a variety of immune system defects. Methods This study looked at Fas, T cell, BCl2, and P53 activity in people with CKD, end stage renal disease (ESRD), and stable...

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Bibliographic Details
Published in:Molecular biology reports 2021-10, Vol.48 (10), p.6857-6862
Main Authors: Zakaria, Mahmoud M., Derbala, Safaa A., Salem, Ayman E., EL-Agroudy, Amgad E., El-Tantawy, Fatma M.
Format: Article
Language:English
Subjects:
Animal Anatomy
Animal Biochemistry
Apoptosis
Apoptosis - genetics
Biomarkers - blood
Biomedical and Life Sciences
C-Reactive Protein - metabolism
CD4 antigen
CD8 antigen
Creatinine - blood
FasL protein
Female
Gene expression
Gene Expression Regulation
Histology
Humans
Immune system
Inflammation
Inflammation - pathology
Kidney diseases
Kidney Failure, Chronic - blood
Kidney Failure, Chronic - genetics
Kidney Failure, Chronic - pathology
Life Sciences
Lymphocytes T
Male
Middle Aged
Morphology
Original Article
p53 Protein
Peripheral blood
Potassium - blood
Renal Insufficiency, Chronic - blood
Renal Insufficiency, Chronic - genetics
Renal Insufficiency, Chronic - pathology
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Summary:Background Chronic kidney disease (CKD) is condition characterized by a gradual loss of kidney function, patient with CKD suffering from a variety of immune system defects. Methods This study looked at Fas, T cell, BCl2, and P53 activity in people with CKD, end stage renal disease (ESRD), and stable controls. Results The CD4+ and CD8+ levels in ESRD patients’ peripheral blood were slightly lower than those in CKD patients. The CKD and ESRD groups had slightly higher Fas and FasL mRNA expression and slightly lower BCl2 mRNA gene expression than the normal control group (P 
ISSN:0301-4851
1573-4978
DOI:10.1007/s11033-021-06684-4