Spatiofunctional Dynamics of NKX3.1 to Safeguard the Prostate from Cancer

A novel role of NKX3.1 in the mitochondria regulating the transcription of the electron transport chain components is reported. Mechanistically, HSPA9 chaperones NKX3.1 into the mitochondria in response to oxidative stress to regulate reactive oxygen species and suppress tumor initiation. .

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Bibliographic Details
Published in:Cancer discovery 2021-09, Vol.11 (9), p.2132-2134
Main Authors: Finch, Andrew J, Baena, Esther
Format: Article
Language:English
Subjects:
Homeodomain Proteins - genetics
Humans
Male
Prostate
Prostatic Neoplasms
Reactive Oxygen Species
Transcription Factors - genetics
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Description
Summary:A novel role of NKX3.1 in the mitochondria regulating the transcription of the electron transport chain components is reported. Mechanistically, HSPA9 chaperones NKX3.1 into the mitochondria in response to oxidative stress to regulate reactive oxygen species and suppress tumor initiation. .
ISSN:2159-8274
2159-8290
DOI:10.1158/2159-8290.CD-21-0861