Recent advances in microneedles-based drug delivery device in the diagnosis and treatment of cancer

• Published in: Journal of controlled release 2021-10, Vol.338, p.394-409
• Main Authors: Singh, Vanshikha, Kesharwani, Prashant
• Format: Article
• Language: English
• Subjects: Cancer; Chemotherapy; Hydrogels; Immunotherapy; Microneedles; Photodynamic therapy; Photothermal therapy; Vaccines
• ISSN: 0168-3659; 1873-4995
• DOI: 10.1016/j.jconrel.2021.08.054

Microneedles are unique, novel and an effective approach designed to deliver therapeutic agents and immunobiologicals in several diseases. These tiny needle patches are designed to load vaccine, small or large drug molecule, heavy molecular weighted proteins, genes, antibodies, nanoparticles and many more. These nanoparticles loaded microneedles deliver drugs deep within the skin near underlying neutrophils, langerhans and dendritic cells and induces required immunological response. With the drawbacks associated with conventional methods of cancer chemotherapy, the focus was shifted towards use of microneedles in not just anti-cancer vaccine/drug delivery but also for their early diagnosis. This delivery device is also suited for synergistic approaches such as chemotherapy or gene therapy combined with photothermal or photodynamic therapy. The painless self-administrative device offers an alternative over traditional routes of drug delivery including systemic administration via hypodermic needles. Additionally, these microneedles can be fabricated and altered in shape, size and geometry and the material polymer can be chosen depending on use and release mechanism. This review consolidates positive results obtained from studies done for different type of microneedle array in several tumor cell lines and animal models. It further highlights the use of biodegradable polymers such as hydrogel or any dissolving polymer that can be utilized for sustained codelivery of drug/vaccine to shun the need of multiple dosing. It covers the existing limitations that still needs to be resolved and further highlights on the future aspects of their use in cancer therapy. [Display omitted] •Microneedles are promising devices used for painless transdermal drug delivery.•Biological effects of therapeutic agents can be improved by tuning their release behavior.•Microneedles can be employed for immunotherapy.•Combinatory approaches with two different therapies can be utilized by microneedles.•Microneedles are suggested for tissue fluid early detection of cancer.