A new equation to estimate daily natriuresis from parameters in plasma and spot urine sample in the Chilean population

• Published in: Revista medíca de Chile 2021-02, Vol.149 (2), p.178-186
• Main Authors: Sepúlveda, Rodrigo A, Huidobro E, Juan Pablo, Jara, Aquiles, Tagle, Rodrigo
• Format: Article
• Language: Spanish
• ISSN: 0717-6163
• DOI: 10.4067/s0034-98872021000200178

BACKGROUNDExcessive sodium intake is associated with increased cardiovascular morbidity and mortality. Daily sodium intake is usually inferred from sodium excretion in a 24-hour urine collection, which is cumbersome and prone to errors. Different formulas have attempted to estimate 24-hour urinary sodium from a spot urine sample. Unfortunately, their concordances are insufficient and have not been tested in our population. AIMTo develop an equation to predict 24-hour urine sodium from parameters in plasma and spot urine samples. To validate the equation and compare it with other formulas in Chilean population. MATERIAL AND METHODSAnalysis of 24-hour urine collections, plasma sample and spot urine sample from 174 adult outpatients (81% females) with an estimated glomerular filtration rate (eGFR) ≥ 60 mL/min/1.73m2. These were collected between 2015 and 2019 using standardized methods and educating patients about the correct method to collect 24 h urine samples. In all these patients, creatinine and electrolytes were measured in plasma and urine. A new equation was developed using a multiple linear regression model. RESULTSTwenty-four-hour urine sodium excretion was significantly correlated with age, weight, height, eGFR, plasma osmolarity, urine electrolytes and parameters obtained from spot urine sample, among others. The new equation had a linear correlation with 24-hour natriuresis of 0.91 and the concordance was 0.9. The predictive capacity of the new equation was better than the existing formulas. CONCLUSIONSWe developed a formula to accurately predict daily natriuresis in the Chilean population.