Runner's niche: multipurpose stromal cells maintained by exercise

Using newly developed reporter and lineage-tracing mice, Shen et al. found perivascular stromal cells coexpressing osteolectin and leptin receptor in the bone marrow that specifically supported lymphoid progenitors, served as osteoblast progenitors, and were maintained by mechanical stimulation. Exe...

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Bibliographic Details
Published in:Trends in immunology 2021-10, Vol.42 (10), p.841-843
Main Authors: Dietlein, Nikolaus, Rodewald, Hans-Reimer
Format: Article
Language:English
Subjects:
Biomedical materials
Bone growth
Bone marrow
Exercise
Fractures
Gene expression
Kinases
Lymphopoiesis
Mechanical stimuli
Osteogenesis
Osteoprogenitor cells
Physical fitness
Progenitor cells
Stem cells
Stromal cells
Thymus gland
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Summary:Using newly developed reporter and lineage-tracing mice, Shen et al. found perivascular stromal cells coexpressing osteolectin and leptin receptor in the bone marrow that specifically supported lymphoid progenitors, served as osteoblast progenitors, and were maintained by mechanical stimulation. Exercise may thus have joint positive influences on lymphopoiesis and bone formation.
ISSN:1471-4906
1471-4981
DOI:10.1016/j.it.2021.08.007