Soluble Factors Involved in Cancer Cell–Macrophage Interaction Promote Breast Cancer Growth

Background/Aim: Recent studies have indicated the clinical significance of tumor-associated macrophages (TAMs) in breast cancer; however, the detailed mechanisms of cell–cell interactions between TAMs and cancer cells remain unclear. Materials and Methods: In vitro cell culture studies using human m...

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Bibliographic Details
Published in:Anticancer research 2021-09, Vol.41 (9), p.4249-4258
Main Authors: Yonemitsu, Kimihiro, Miyasato, Yuko, Shiota, Takuya, Shinchi, Yusuke, Fujiwara, Yukio, Hosaka, Seiji, Yamamoto, Yutaka, Komohara, Yoshihiro
Format: Article
Language:English
Subjects:
Animal models
Biomedical materials
Breast cancer
Cell culture
Cell interactions
Cytokines
Growth factors
In vitro methods and tests
Infiltration
Interleukin 6
Macrophages
Metastases
Monocytes
Osteopontin
Tumor cell lines
Tumors
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Summary:Background/Aim: Recent studies have indicated the clinical significance of tumor-associated macrophages (TAMs) in breast cancer; however, the detailed mechanisms of cell–cell interactions between TAMs and cancer cells remain unclear. Materials and Methods: In vitro cell culture studies using human monocyte-derived macrophages and breast cancer cell lines were performed to test which cytokines would be involved in cell-cell interactions between cancer cells and macrophages. In addition, studies using human resected samples and animal breast cancer models were performed to examine the significance of TAMs in cancer development. Results: Osteopontin, HB-EGF, and IL-6 were suggested to be macrophage-derived growth factors for breast cancer cells. FROUNT inhibitor significantly blocked TAM infiltration and subcutaneous tumor growth in an E0771 mouse breast cancer model. Conclusion: TAMs express growth factors, such as osteopontin, for cancer cells, and targeting of TAM infiltration might be a promising approach for anti-breast cancer therapy.
ISSN:0250-7005
1791-7530
DOI:10.21873/anticanres.15229