Maternal smoking during pregnancy and asthma during the first year of life: a comparative study between smokers and nonsmoker mothers

• Published in: Allergologia et immunopathologia 2021, Vol.49 (5), p.32-41
• Main Authors: Rivas-Juesas, Cristina, Monge, Lucía Fernández, Vicente, Ana Delgado, García, Ana Ledo, Crespo, Maribel Giner, Sinisterra, Alicia Coret
• Format: Article
• Language: English
• Subjects: Asthma; Asthma - epidemiology; Birth weight; Breastfeeding & lactation; Bronchitis; Cesarean section; Cigarettes; Dermatitis; Ear diseases; Eczema; Female; Food allergies; Gestational age; Hospitals; Humans; Male; Medical records; Mothers; Non-Smokers; Observational studies; Pneumonia; Population; Pregnancy; Smokers; Smoking; Smoking - epidemiology; Statistical analysis; Variables; Womens health
• ISSN: 0301-0546; 1578-1267
• DOI: 10.15586/aei.v49i5.439

We investigated the relationship between maternal smoking in pregnancy and health care problems in the offspring during the first year of life, particularly asthma. A cohort of 648 consecutive infants born at term and alive at Hospital de Sagunto (Valencia, Spain) over one year period was followed for 12 months. Clinical data of the infants were prospectively collected from the database of ambulatory medical records (ABUCASIS) of the Valencia health system. Smoking during pregnancy was recorded in 164 (25.3%) mothers. During the first year of life, asthma was diagnosed in 101 infants, with an incidence of 15.7%. The diagnoses of asthma (25.6% vs. 12.3%; P < 0.0001) and bronchiolitis (44.5% vs. 28.6%; P = 0.0002) during the first year of life were more common among infants in the smoking group. The probability of developing asthma during the first year of life was two-fold higher for the male gender and 2.5 times higher when mothers smoked while pregnant. Up to 52% of asthma cases could have been avoided in infants born to smoking mothers if they did not smoke during pregnancy. Infants in the smoking group showed a lower weight and length at birth than infants in the nonsmoking group differences almost disappeared at 6 months and 12 months. Asthma during the first year of life showed a clear relationship with maternal smoking in pregnancy. Pregnant women should be advised of the significant perinatal risk for respiratory diseases associated with tobacco use.