Synthesis of α‐Amino Tertiary Alkylperoxides by Lewis Acid‐Catalyzed Peroxidation of 1,3,5‐Triazines

α‐Substituted peroxides have been found in natural products and are widely used as anti‐malarial agents. Zn(OTf)2‐catalyzed peroxidation of 1,3,5‐triazines has been developed, accessing diversely substituted α‐amino tertiary alkylperoxides with high efficiency. Mechanistic investigations and useful...

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Bibliographic Details
Published in:Chemistry, an Asian journal an Asian journal, 2021-11, Vol.16 (21), p.3487-3491
Main Authors: Liu, Lijuan, Shi, Zhichao, Zhang, Xun, Zhan, Feng, Lin, Jin‐Shun, Jiang, Yuyang
Format: Article
Language:English
Subjects:
1,3,5-triazines
Chemistry
Lewis acid
Natural products
peroxidation
Peroxides
Substitutes
α-amino tertiary alkylperoxides
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Summary:α‐Substituted peroxides have been found in natural products and are widely used as anti‐malarial agents. Zn(OTf)2‐catalyzed peroxidation of 1,3,5‐triazines has been developed, accessing diversely substituted α‐amino tertiary alkylperoxides with high efficiency. Mechanistic investigations and useful synthetic application of the products have also been presented. Zn(OTf)2‐catalyzed peroxidation of 1,3,5‐triazines has been developed, accessing diversely substituted α‐amino tertiary alkylperoxides with high efficiency under mild conditions. Moreover, the three‐component reaction of amine, hydroperoxide, and paraformaldehyde was also proved to give the desired product. Mechanistic investigations and useful synthetic application of the products have also been presented.
ISSN:1861-4728
1861-471X
DOI:10.1002/asia.202100833