Photoredox relay-catalyzed gem -difluoroallylation of alkyl iodides

Herein, a new example of relay catalysis, using a combination of Mn 2 (CO) 10 and an iridium-based photocatalyst, is reported. In our relay catalytic reaction, the Mn catalyst and iridium-based photocatalyst catalyze the reaction at different stages in the desired sequence under the same reaction co...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2021-09, Vol.57 (76), p.9768-9771
Main Authors: Guo, Yuanqiang, Cao, Yunpeng, Song, Hongjian, Liu, Yuxiu, Wang, Qingmin
Format: Article
Language:English
Subjects:
Catalysis
Functional groups
Iodides
Iridium
Photocatalysts
Relay
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Summary:Herein, a new example of relay catalysis, using a combination of Mn 2 (CO) 10 and an iridium-based photocatalyst, is reported. In our relay catalytic reaction, the Mn catalyst and iridium-based photocatalyst catalyze the reaction at different stages in the desired sequence under the same reaction conditions, and do not inhibit each other. This convenient method transforms a broad scope of alkyl iodides into the corresponding gem -difluoroalkenes via C(sp 3 )–C(sp 3 ) bond construction. The protocol has good functional group tolerance and is suitable for the late-stage modification of multifunctional complex molecules.
ISSN:1359-7345
1364-548X
DOI:10.1039/d1cc04284j